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Pdpr Gene Detail
Summary
  • Symbol
    Pdpr
  • Name
    pyruvate dehydrogenase phosphatase regulatory subunit
  • Synonyms
    4930402E16Rik, mKIAA1990
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442188
    NCBI Gene: 319518
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:111821262-111863706 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442188
 protein coding gene Chr8:111821232-111866402 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034136
 protein coding gene Chr8:113827517-113874404 (+)
A/J MGP_AJ_G0034115
 protein coding gene Chr8:109209683-109254447 (+)
AKR/J MGP_AKRJ_G0034042
 protein coding gene Chr8:112406455-112455043 (+)
BALB/cJ MGP_BALBcJ_G0034109
 protein coding gene Chr8:109385877-109430703 (+)
C3H/HeJ MGP_C3HHeJ_G0033820
 protein coding gene Chr8:113129047-113173538 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034629
 protein coding gene Chr8:117824144-117874584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031571
 protein coding gene Chr8:102187536-102231212 (+)
CAST/EiJ MGP_CASTEiJ_G0033147
 protein coding gene Chr8:112743567-112790604 (+)
CBA/J MGP_CBAJ_G0033794
 protein coding gene Chr8:121830572-121882478 (+)
DBA/2J MGP_DBA2J_G0033949
 protein coding gene Chr8:108498982-108542882 (+)
FVB/NJ MGP_FVBNJ_G0033893
 protein coding gene Chr8:107457159-107499316 (+)
LP/J MGP_LPJ_G0034039
 protein coding gene Chr8:114002214-114047163 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033939
 protein coding gene Chr8:124721619-124767478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034648
 protein coding gene Chr8:112379368-112427960 (+)
PWK/PhJ MGP_PWKPhJ_G0032850
 protein coding gene Chr8:108077855-108123506 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032689
 protein coding gene Chr8:111060163-111100558 (+)
WSB/EiJ MGP_WSBEiJ_G0033263
 protein coding gene Chr8:113059063-113105897 (+)



Homology
more
  • Human Ortholog
    PDPR, pyruvate dehydrogenase phosphatase regulatory subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDPR, pyruvate dehydrogenase phosphatase regulatory subunit
  • Synonyms
    PDP3
  • Links
    NCBI Gene ID: 55066
    neXtProt AC: NX_Q8NCN5
    UniProt: Q8NCN5

  • Chr Location
    16q22.1; chr16:70113626-70163427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033624 Ensembl Gene Model | MGI Sequence Detail 42445 C57BL/6J ±  kb
    transcript ENSMUST00000039333 Ensembl | MGI Sequence Detail 4938 Not Applicable  
    polypeptide ENSMUSP00000046639 Ensembl | MGI Sequence Detail 878 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012517 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR006222 Aminomethyltransferase, folate-binding domain
      IPR006076 FAD dependent oxidoreductase
      IPR032503 FAD dependent oxidoreductase, central domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
      IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal
      IPR027266 GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142683
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:236179 Bowman CE, et al., Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Mol Cell Biol. 2016 Aug 1;36(15):2089-104
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory