Lrrc41 MGI Mouse Gene Detail - MGI:2441984 - leucine rich repeat containing 41

Symbol

Lrrc41
Name

leucine rich repeat containing 41
Synonyms

D630045E04Rik, D730026A16Rik, MUF1

Feature Type

protein coding gene
IDs

MGI:2441984
NCBI Gene: 230654
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:115932466-115954240 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.10 cM
Mapping Data

2 experiments

SNPs within 2kb

882 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441984	protein coding gene	Chr4:115932466-115954306 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028617	protein coding gene	Chr4:116923747-116946347 (+)
A/J	MGP_AJ_G0028578	protein coding gene	Chr4:112468606-112490372 (+)
AKR/J	MGP_AKRJ_G0028528	protein coding gene	Chr4:114878839-114902191 (+)
BALB/cJ	MGP_BALBcJ_G0028599	protein coding gene	Chr4:113093503-113122910 (+)
C3H/HeJ	MGP_C3HHeJ_G0028313	protein coding gene	Chr4:116459502-116481257 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029040	protein coding gene	Chr4:121474656-121496412 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026324	protein coding gene	Chr4:106508718-106530933 (+)
CAST/EiJ	MGP_CASTEiJ_G0027747	protein coding gene	Chr4:113685012-113708184 (+)
CBA/J	MGP_CBAJ_G0028280	protein coding gene	Chr4:124773048-124797453 (+)
DBA/2J	MGP_DBA2J_G0028428	protein coding gene	Chr4:113112429-113134224 (+)
FVB/NJ	MGP_FVBNJ_G0028396	protein coding gene	Chr4:111605563-111630330 (+)
LP/J	MGP_LPJ_G0028530	protein coding gene	Chr4:117137806-117159590 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028423	protein coding gene	Chr4:129775518-129797202 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029077	protein coding gene	Chr4:116041841-116063761 (+)
PWK/PhJ	MGP_PWKPhJ_G0027473	protein coding gene	Chr4:109880163-109902627 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027296	protein coding gene	Chr4:112291666-112316351 (+)
WSB/EiJ	MGP_WSBEiJ_G0027826	protein coding gene	Chr4:115911139-115934093 (+)

Human Ortholog

LRRC41, leucine rich repeat containing 41

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC41, leucine rich repeat containing 41
Synonyms

MUF1, PP7759
Links

HGNC:16917

NCBI Gene ID: 10489

UniProt: Q15345
Chr Location

1p34.1-p33; chr1:46261196-46303616 (-) GRCh38

MGI Vertebrate Homology

Lrrc41 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRC41
Gene Tree

Lrrc41

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

9
Radiation induced

1
Targeted

1
Genomic Mutations

4 involving Lrrc41
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

11
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc41

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All Sequences

81
RefSeq

8
UniProt

3
CCDS

CCDS84786.1

Ensembl

ENSMUSG00000028703 (Evidence)
NCBI Gene

230654

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028703	Ensembl Gene Model \| MGI Sequence Detail	21775	C57BL/6J	± kb
transcript	ENSMUST00000030471	Ensembl \| MGI Sequence Detail	3065	Not Applicable
polypeptide	ENSMUSP00000030471	Ensembl \| MGI Sequence Detail	807	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009936 leucine-rich repeat-containing protein 41

(term hierarchy)
InterPro Domains

IPR026137 Leucine-rich repeat-containing 41

IPR032675 Leucine-rich repeat domain superfamily
GlyGen

Q8K1C9 1 site, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 16

Microarray probesets 6

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MGI:2140149, MGI:2140600, MGI:2441986

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrrc41:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38493	Chr4:115932541-115932554 (+)	82 bp
Tssr38494	Chr4:115932573-115932584 (+)	113 bp
Tssr38495	Chr4:115932589-115932606 (+)	132 bp
Tssr38496	Chr4:115932634-115932658 (+)	180 bp
Tssr38497	Chr4:115932659-115932670 (+)	199 bp
Tssr38498	Chr4:115932720-115932731 (+)	260 bp
Tssr38499	Chr4:115932734-115932748 (+)	275 bp
Tssr38500	Chr4:115932763-115932764 (+)	298 bp
Tssr38501	Chr4:115952791-115952819 (+)	20,339 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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