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Ghsr Gene Detail
Summary
  • Symbol
    Ghsr
  • Name
    growth hormone secretagogue receptor
  • Synonyms
    C530020I22Rik, Ghsr1a
Location &
Maps
more
  • Sequence Map
    Chr3:27425500-27432159 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 10.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441906
 protein coding gene Chr3:27425500-27433384 (+)
129S1/SvImJ ENSMUSG00200023093
 protein coding gene Chr3:24149366-24156025 (+)
A/J ENSMUSG00195019585
 protein coding gene Chr3:24279270-24285931 (+)
AKR/J ENSMUSG00220008060
 protein coding gene Chr3:24284108-24290769 (+)
BALB/cJ ENSMUSG00180030047
 protein coding gene Chr3:24256739-24263398 (+)
C3H/HeJ ENSMUSG00175026910
 protein coding gene Chr3:24270307-24276968 (+)
C57BL/6NJ ENSMUSG00215010788
 protein coding gene Chr3:24520959-24527618 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024890
 protein coding gene Chr3:22514434-22521123 (+)
CAST/EiJ ENSTCUG00005024652
 protein coding gene Chr3:24102900-24109558 (+)
CBA/J ENSMUSG00210033755
 protein coding gene Chr3:24256195-24262856 (+)
DBA/2J ENSMUSG00185009275
 protein coding gene Chr3:24488702-24495360 (+)
FVB/NJ ENSMUSG00205007667
 protein coding gene Chr3:23810564-23817222 (+)
JF1/MsJ ENSUMUG00000002167
 protein coding gene Chr3:23969614-23976293 (+)
LP/J ENSMUSG00230001181
 protein coding gene Chr3:26378935-26385593 (+)
NOD/ShiLtJ ENSMUSG00190029489
 protein coding gene Chr3:24547949-24554607 (+)
NZO/HlLtJ ENSMUSG00225006961
 protein coding gene Chr3:29014607-29021266 (+)
PWK/PhJ ENSLUMG00010032399
 protein coding gene Chr3:23952400-23959074 (+)
SPRET/EiJ ENSMSPG00010022055
 protein coding gene Chr3:24319005-24324310 (+)
WSB/EiJ ENSIUOG00005034639
 protein coding gene Chr3:24523146-24529805 (+)



Homology
more
  • Human Ortholog
    GHSR, growth hormone secretagogue receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GHSR, growth hormone secretagogue receptor
  • Synonyms
    GHDP, GHS-R1a, GHSR-1a
  • Links
    NCBI Gene ID: 2693
    UniProt: Q92847

  • Chr Location
    3q26.31; chr3:172443291-172448456 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GHSR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homeostasis is disrupted by inactivation of this gene, namely growth hormone release and appetite stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    150
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    45
  • cDNA Data
    7
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051136 Ensembl Gene Model | MGI Sequence Detail 6660 C57BL/6J ±  kb
    transcript ENSMUST00000057186 Ensembl | MGI Sequence Detail 4433 Not Applicable  
    polypeptide ENSMUSP00000061153 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 16
      Phenotypes 144
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:381205 Han HW, et al., Myeloid GHSR Deficiency Protects Against Thermogenic Impairment in Aging Through Immune Remodeling of Brown Adipose Tissue. Cells. 2026 Feb 9;15(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory