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Cdc42bpa Gene Detail
Summary
  • Symbol
    Cdc42bpa
  • Name
    CDC42 binding protein kinase alpha
  • Synonyms
    A930014J19Rik, DMPK-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441841
    NCBI Gene: 226751
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:179788037-179993168 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4598 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441841
 protein coding gene Chr1:179787058-179993171 (+)
129S1/SvImJ ENSMUSG00200022694
 protein coding gene Chr1:177540134-177745263 (+)
A/J ENSMUSG00195039167
 protein coding gene Chr1:177160346-177363398 (+)
AKR/J ENSMUSG00220019861
 protein coding gene Chr1:176394214-176598537 (+)
BALB/cJ ENSMUSG00180032049
 protein coding gene Chr1:177191281-177396436 (+)
C3H/HeJ ENSMUSG00175034950
 protein coding gene Chr1:177367158-177572298 (+)
C57BL/6NJ ENSMUSG00215020183
 protein coding gene Chr1:176591967-176797099 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014973
 protein coding gene Chr1:169817495-170019201 (+)
CAST/EiJ ENSTCUG00005042618
 protein coding gene Chr1:175110546-175313313 (+)
CBA/J ENSMUSG00210018726
 protein coding gene Chr1:177030849-177232811 (+)
DBA/2J ENSMUSG00185029270
 protein coding gene Chr1:181649574-181851535 (+)
FVB/NJ ENSMUSG00205021225
 protein coding gene Chr1:176087504-176291812 (+)
JF1/MsJ ENSUMUG00000007404
 protein coding gene Chr1:180624867-180832890 (+)
LP/J ENSMUSG00230027995
 protein coding gene Chr1:181206020-181411144 (+)
NOD/ShiLtJ ENSMUSG00190029910
 protein coding gene Chr1:177053021-177258151 (+)
NZO/HlLtJ ENSMUSG00225011029
 protein coding gene Chr1:184961855-185166154 (+)
PWK/PhJ ENSLUMG00010016176
 protein coding gene Chr1:175903379-176105346 (+)
SPRET/EiJ ENSMSPG00010033800
 protein coding gene Chr1:179334838-179550246 (+)
WSB/EiJ ENSIUOG00005010998
 protein coding gene Chr1:176258025-176475473 (+)



Homology
more
  • Human Ortholog
    CDC42BPA, CDC42 binding protein kinase alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC42BPA, CDC42 binding protein kinase alpha
  • Synonyms
    MRCK, MRCKA, MRCKalpha, PK428
  • Links
    NCBI Gene ID: 8476
    UniProt: Q5VT25

  • Chr Location
    1q42.13; chr1:226989858-227318492 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026490 Ensembl Gene Model | MGI Sequence Detail 205132 C57BL/6J ±  kb
transcript ENSMUST00000212756 Ensembl | MGI Sequence Detail 5247 Not Applicable  
polypeptide ENSMUSP00000148469 Ensembl | MGI Sequence Detail 1748 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000005205 serine/threonine-protein kinase MRCK alpha
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR046349 C1-like domain superfamily
    IPR001180 Citron homology (CNH) domain
    IPR000095 CRIB domain
    IPR020454 Diacylglycerol/phorbol-ester binding
    IPR060769 EIF3B-like, beta-propeller domain superfamily
    IPR031597 KELK-motif containing domain
    IPR057529 MRCK/ROCK kinase, PH domain
    IPR014930 Myotonic dystrophy protein kinase, coiled coil
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR017441 Protein kinase, ATP binding site
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR017892 Protein kinase, C-terminal
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR050839 Rho-associated Serine/Threonine Kinase
    IPR008271 Serine/threonine-protein kinase, active site
    IPR026611 Serine/threonine-protein kinase MRCK alpha, catalytic domain
  • GlyGen
    Q3UU96 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:314111 Kwa MQ, et al., MRCKalpha Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model. Cells. 2021 Apr 19;10(4)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory