Sh2d7 MGI Mouse Gene Detail - MGI:2441692

Symbol

Sh2d7
Name

SH2 domain containing 7
Synonyms

4933412E14Rik

Feature Type

protein coding gene
IDs

MGI:2441692
NCBI Gene: 244885
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:54441430-54452304 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 29.70 cM
Mapping Data

1 experiment

SNPs within 2kb

380 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441692	protein coding gene	Chr9:54441407-54452314 (+)
129S1/SvImJ	ENSMUSG00200033629	protein coding gene	Chr9:51568894-51579766 (+)
A/J	ENSMUSG00195036142	protein coding gene	Chr9:51266897-51277768 (+)
AKR/J	ENSMUSG00220028942	protein coding gene	Chr9:51399842-51410716 (+)
BALB/cJ	ENSMUSG00180015141	protein coding gene	Chr9:51380268-51391139 (+)
C3H/HeJ	ENSMUSG00175019671	protein coding gene	Chr9:51392108-51402979 (+)
C57BL/6NJ	ENSMUSG00215017277	protein coding gene	Chr9:51365434-51376307 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032228	protein coding gene	Chr9:51290784-51296886 (+)
CAST/EiJ	ENSTCUG00005019773	protein coding gene	Chr9:51299323-51310183 (+)
CBA/J	ENSMUSG00210031866	protein coding gene	Chr9:51495648-51506545 (+)
DBA/2J	ENSMUSG00185037596	protein coding gene	Chr9:51525059-51535930 (+)
FVB/NJ	ENSMUSG00205036814	protein coding gene	Chr9:51802740-51813617 (+)
JF1/MsJ	ENSUMUG00000036969	protein coding gene	Chr9:51533689-51544518 (+)
LP/J	ENSMUSG00230037148	protein coding gene	Chr9:51768896-51779770 (+)
NOD/ShiLtJ	ENSMUSG00190035812	protein coding gene	Chr9:51582480-51593350 (+)
NZO/HlLtJ	ENSMUSG00225027590	protein coding gene	Chr9:51788277-51799151 (+)
PWK/PhJ	ENSLUMG00010033422	protein coding gene	Chr9:51496097-51506913 (+)
SPRET/EiJ	ENSMSPG00010021669	protein coding gene	Chr9:52480828-52491839 (+)
WSB/EiJ	ENSIUOG00005033781	protein coding gene	Chr9:50994073-51004946 (+)

Human Ortholog

SH2D7, SH2 domain containing 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH2D7, SH2 domain containing 7
Links

HGNC:34549

NCBI Gene ID: 646892

UniProt: A6NKC9
Chr Location

15q25.1; chr15:78077808-78104370 (+) GRCh38

MGI Vertebrate Homology

Sh2d7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SH2D7
Gene Tree

Sh2d7

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

2
GO References

1

Molecular Function

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

621
Tissues

11
cDNA Data

5
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

1
CCDS

CCDS23190.2

Ensembl

ENSMUSG00000046460 (Evidence)
NCBI Gene

244885

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046460	Ensembl Gene Model \| MGI Sequence Detail	10875	C57BL/6J	± kb
transcript	ENSMUST00000118413	Ensembl \| MGI Sequence Detail	3045	Not Applicable
polypeptide	ENSMUSP00000113298	Ensembl \| MGI Sequence Detail	458	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030529 SH2 domain-containing protein 7

(term hierarchy)
InterPro Domains

IPR035885 SH2D7, SH2 domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

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All nucleic 5

cDNA 5

Microarray probesets 2

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sh2d7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85159	Chr9:54441404-54441411 (+)	-22 bp
Tssr85160	Chr9:54446268-54446277 (+)	4,843 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24