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Fam221b Gene Detail
Summary
  • Symbol
    Fam221b
  • Name
    family with sequence similarity 221, member B
  • Synonyms
    4930412F15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441678
    NCBI Gene: 242408
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43659622-43668859 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    329 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441678
 protein coding gene Chr4:43659622-43669145 (-)
129S1/SvImJ ENSMUSG00200004767
 protein coding gene Chr4:39695653-39704657 (-)
A/J ENSMUSG00195003304
 protein coding gene Chr4:40168631-40177639 (-)
AKR/J ENSMUSG00220030830
 protein coding gene Chr4:39855776-39864783 (-)
BALB/cJ ENSMUSG00180022649
 protein coding gene Chr4:39755383-39764391 (-)
C3H/HeJ ENSMUSG00175021660
 protein coding gene Chr4:39899677-39908685 (-)
C57BL/6NJ ENSMUSG00215023732
 protein coding gene Chr4:39679982-39689501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025949
 protein coding gene Chr4:37751052-37760056 (-)
CAST/EiJ ENSTCUG00005003956
 protein coding gene Chr4:39947017-39956099 (-)
CBA/J ENSMUSG00210007101
 protein coding gene Chr4:39590454-39599967 (-)
DBA/2J ENSMUSG00185006002
 protein coding gene Chr4:39953896-39963409 (-)
FVB/NJ ENSMUSG00205022526
 protein coding gene Chr4:39197192-39206705 (-)
JF1/MsJ ENSUMUG00000021929
 protein coding gene Chr4:40193031-40202126 (-)
LP/J ENSMUSG00230040996
 protein coding gene Chr4:43507830-43517349 (-)
NOD/ShiLtJ ENSMUSG00190005466
 protein coding gene Chr4:39814083-39823090 (-)
NZO/HlLtJ ENSMUSG00225006109
 protein coding gene Chr4:48097007-48106526 (-)
PWK/PhJ ENSLUMG00010006547
 protein coding gene Chr4:39191924-39201007 (-)
SPRET/EiJ ENSMSPG00010021339
 protein coding gene Chr4:40132097-40141132 (-)
WSB/EiJ ENSIUOG00005049338
 protein coding gene Chr4:39570080-39579592 (-)



Homology
more
  • Human Ortholog
    FAM221B, family with sequence similarity 221 member B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM221B, family with sequence similarity 221 member B
  • Synonyms
    C9orf128
  • Links
    NCBI Gene ID: 392307
    UniProt: A6H8Z2

  • Chr Location
    9p13.3; chr9:35816391-35828747 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 1 genetic background
    6 phenotype references
  • All Mutations and Alleles
    8
  • Chemically and radiation induced
    1
  • Endonuclease-mediated
    5
  • Targeted
    2
  • Genomic Mutations
    1 involving Fam221b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    22 strains or lines available
Male mice homozygous for a null allele exhibit normal fecundity.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 242408 NCBI Gene Model | MGI Sequence Detail 9238 C57BL/6J ±  kb
transcript NM_175517 RefSeq | MGI Sequence Detail 1763 C57BL/6  
polypeptide Q8C627 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR026755 Protein FAM221A/B
  • GlyGen
    Q8C627 1 site
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory