Lamp3 MGI Mouse Gene Detail - MGI:2441659 - lysosomal-associated membrane protein 3

Symbol

Lamp3
Name

lysosomal-associated membrane protein 3
Synonyms

1200002D17Rik, Cd208, DC-LAMP, TSC403

Feature Type

protein coding gene
IDs

MGI:2441659
NCBI Gene: 239739
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr16:19472131-19525115 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 12.17 cM
Mapping Data

1 experiment

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441659	protein coding gene	Chr16:19472128-19525125 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022632	protein coding gene	Chr16:16934713-16982694 (-)
A/J	MGP_AJ_G0022594	protein coding gene	Chr16:16135379-16185984 (-)
AKR/J	MGP_AKRJ_G0022569	protein coding gene	Chr16:16782263-16836234 (-)
BALB/cJ	MGP_BALBcJ_G0022598	protein coding gene	Chr16:16289150-16340303 (-)
C3H/HeJ	MGP_C3HHeJ_G0022363	protein coding gene	Chr16:16929884-16978868 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023049	protein coding gene	Chr16:17271374-17319481 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020566	protein coding gene	Chr16:16114059-16158877 (-)
CAST/EiJ	MGP_CASTEiJ_G0021893	protein coding gene	Chr16:16902066-16962917 (-)
CBA/J	MGP_CBAJ_G0022335	protein coding gene	Chr16:18013782-18063386 (-)
DBA/2J	MGP_DBA2J_G0022467	protein coding gene	Chr16:16031336-16084595 (-)
FVB/NJ	MGP_FVBNJ_G0022442	protein coding gene	Chr16:16094974-16150745 (-)
LP/J	MGP_LPJ_G0022534	protein coding gene	Chr16:16704406-16757391 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022462	protein coding gene	Chr16:17666892-17738957 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023060	protein coding gene	Chr16:16697197-16759550 (-)
PWK/PhJ	MGP_PWKPhJ_G0021634	protein coding gene	Chr16:16319102-16366721 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021463	protein coding gene	Chr16:16528942-16582088 (-)
WSB/EiJ	MGP_WSBEiJ_G0021937	protein coding gene	Chr16:16712335-16764585 (-)

Human Ortholog

LAMP3, lysosomal associated membrane protein 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMP3, lysosomal associated membrane protein 3
Synonyms

CD208, DCLAMP, DC LAMP, DC-LAMP, LAMP, LAMP-3, TSC403
Links

HGNC:14582

NCBI Gene ID: 27074

neXtProt AC: NX_Q9UQV4

UniProt: Q9UQV4
Chr Location

3q27.1; chr3:183122213-183162879 (-) GRCh38.p7

Alliance of Genome Resources

Lamp3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LAMP3
Gene Tree

Lamp3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

5
Literature Summary

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lamp3

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Lamp3 interacts with 260 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS37285.1

Ensembl

ENSMUSG00000041247 (Evidence)
NCBI Gene

239739

			Length	Strain/Species	Flank
genomic	239739	NCBI Gene Model \| MGI Sequence Detail	52985	C57BL/6J	± kb
transcript	NM_177356	RefSeq \| MGI Sequence Detail	3343	C57BL/6
polypeptide	Q7TST5	UniProt \| EBI \| MGI Sequence Detail	411	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001882 lysosome-associated membrane glycoprotein 3

(term hierarchy)
InterPro Domains

IPR002000 Lysosome-associated membrane glycoprotein

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 4
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:324174 Lunding LP, et al., LAMP3 deficiency affects surfactant homeostasis in mice. PLoS Genet. 2021 Jun;17(6):e1009619

TSS for Lamp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140334	Chr16:19525120-19525149 (-)	-20 bp
Tssr140333	Chr16:19525090-19525102 (-)	19 bp
Tssr140332	Chr16:19525055-19525083 (-)	46 bp
Tssr140331	Chr16:19525043-19525047 (-)	70 bp
Tssr140330	Chr16:19520074-19520085 (-)	5,035 bp
Tssr140329	Chr16:19491998-19492007 (-)	33,112 bp
Tssr140328	Chr16:19491917-19491934 (-)	33,189 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22