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Nle1 Gene Detail
Summary
  • Symbol
    Nle1
  • Name
    notchless homolog 1
  • Synonyms
    l11Jus1, l11Jus4, MGC:25690, Nle, notchless
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429770
    NCBI Gene: 217011
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82791594-82799237 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    302 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429770
 protein coding gene Chr11:82791594-82799272 (-)
129S1/SvImJ ENSMUSG00200047996
 protein coding gene Chr11:79914024-79921746 (-)
A/J ENSMUSG00195039768
 protein coding gene Chr11:79780100-79787822 (-)
AKR/J ENSMUSG00220041768
 protein coding gene Chr11:80019952-80027594 (-)
BALB/cJ ENSMUSG00180037233
 protein coding gene Chr11:79980230-79987874 (-)
C3H/HeJ ENSMUSG00175028428
 protein coding gene Chr11:79950466-79958186 (-)
C57BL/6NJ ENSMUSG00215040586
 protein coding gene Chr11:79575538-79583182 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016860
 protein coding gene Chr11:77913484-77921460 (-)
CAST/EiJ ENSTCUG00005041812
 protein coding gene Chr11:79486593-79494309 (-)
CBA/J ENSMUSG00210045889
 protein coding gene Chr11:79768164-79775885 (-)
DBA/2J ENSMUSG00185038107
 protein coding gene Chr11:80053275-80060918 (-)
FVB/NJ ENSMUSG00205026004
 protein coding gene Chr11:79855984-79863627 (-)
JF1/MsJ ENSUMUG00000037136
 protein coding gene Chr11:80426977-80434755 (-)
LP/J ENSMUSG00230028991
 protein coding gene Chr11:81069428-81077150 (-)
NOD/ShiLtJ ENSMUSG00190032442
 protein coding gene Chr11:80091885-80099528 (-)
NZO/HlLtJ ENSMUSG00225038788
 protein coding gene Chr11:83253204-83260846 (-)
PWK/PhJ ENSLUMG00010022961
 protein coding gene Chr11:79949460-79957163 (-)
SPRET/EiJ ENSMSPG00010040340
 protein coding gene Chr11:80373632-80381419 (-)
WSB/EiJ ENSIUOG00005032775
 protein coding gene Chr11:79924600-79932326 (-)



Homology
more
  • Human Ortholog
    NLE1, notchless homolog 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLE1, notchless homolog 1
  • Synonyms
    HUSSY7, NLE, Rsa4
  • Links
    NCBI Gene ID: 54475
    UniProt: Q9NVX2

  • Chr Location
    17q12; chr17:35128730-35142306 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before somite formation, most blastocysts fail to hatch out of the zona pellucida, and apoptosis is increased in the inner cell mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    23
  • cDNA Data
    30
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020692 Ensembl Gene Model | MGI Sequence Detail 7644 C57BL/6J ±  kb
    transcript ENSMUST00000103213 Ensembl | MGI Sequence Detail 1783 Not Applicable  
    polypeptide ENSMUSP00000099502 Ensembl | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144343, MGI:2385862, MGI:2671264, MGI:2671268
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:272621 Gayraud-Morel B, et al., Notchless defines a stage-specific requirement for ribosome biogenesis during lineage progression in adult skeletal myogenesis. Development. 2018 Nov 26;145(23):dev162636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory