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Adam1a Gene Detail
Summary
  • Symbol
    Adam1a
  • Name
    a disintegrin and metallopeptidase domain 1a
  • Synonyms
    fertilin alpha, Ftna, PH-30 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429504
    NCBI Gene: 280668
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121656667-121659758 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 61.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429504
 protein coding gene Chr5:121656639-121660134 (-)
129S1/SvImJ ENSMUSG00200024806
 protein coding gene Chr5:115396455-115399944 (-)
A/J ENSMUSG00195009819
 protein coding gene Chr5:114917731-114921220 (-)
AKR/J ENSMUSG00220040845
 protein coding gene Chr5:114417902-114421397 (-)
BALB/cJ ENSMUSG00180035097
 protein coding gene Chr5:115032289-115035779 (-)
C3H/HeJ ENSMUSG00175025699
 protein coding gene Chr5:117037622-117041123 (-)
C57BL/6NJ ENSMUSG00215027975
 protein coding gene Chr5:115063649-115067144 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027685
 protein coding gene Chr5:114536742-114540234 (-)
CAST/EiJ ENSTCUG00005030594
 protein coding gene Chr5:114306828-114310347 (-)
CBA/J ENSMUSG00210006182
 protein coding gene Chr5:115788480-115791981 (-)
DBA/2J ENSMUSG00185048813
 protein coding gene Chr5:118839945-118843440 (-)
FVB/NJ ENSMUSG00205035157
 protein coding gene Chr5:114693198-114696699 (-)
JF1/MsJ ENSUMUG00000050990
 protein coding gene Chr5:121692812-121696293 (-)
LP/J ENSMUSG00230041490
 protein coding gene Chr5:122918561-122922050 (-)
NOD/ShiLtJ ENSMUSG00190023814
 protein coding gene Chr5:114729241-114732742 (-)
NZO/HlLtJ ENSMUSG00225014139
 protein coding gene Chr5:130596537-130600038 (-)
PWK/PhJ ENSLUMG00010035429
 protein coding gene Chr5:113604422-113607903 (-)
SPRET/EiJ ENSMSPG00010038375
 protein coding gene Chr5:116913179-116916192 (-)
WSB/EiJ ENSIUOG00005017735
 protein coding gene Chr5:117412657-117416152 (-)



Homology
more
  • Human Ortholog
    ADAM1A, ADAM metallopeptidase domain 1A (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM1A, ADAM metallopeptidase domain 1A (pseudogene)
  • Synonyms
    ADAM1, ADAM1AP, ADAM1P, Ftna, FTNAP, PH-30a
  • Links
    NCBI Gene ID: 8759

  • Chr Location
    12q24.12-q24.13; chr12:111899063-111901902 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male infertility with asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 280668 NCBI Gene Model | MGI Sequence Detail 3092 C57BL/6J ±  kb
    transcript NM_172126 RefSeq | MGI Sequence Detail 2982 C57BL/6  
    polypeptide Q60813 UniProt | EBI | MGI Sequence Detail 791 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 3
      cDNA 18

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-27085, MGI:104722, MGI:2141140
    References
    more
    • Summaries
      All 47
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory