Unc5d MGI Mouse Gene Detail - MGI:2389364

Symbol

Unc5d
Name

unc-5 netrin receptor D
Synonyms

D930029E11Rik, Unc5h4

Feature Type

protein coding gene
IDs

MGI:2389364
NCBI Gene: 210801
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:29136745-29709664 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 16.47 cM
Mapping Data

3 experiments

SNPs within 2kb

458 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2389364	protein coding gene	Chr8:29136745-29709698 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033511	protein coding gene	Chr8:26928510-27531105 (-)
A/J	MGP_AJ_G0033490	protein coding gene	Chr8:25908178-26474252 (-)
AKR/J	MGP_AKRJ_G0033415	protein coding gene	Chr8:26729917-27322854 (-)
BALB/cJ	MGP_BALBcJ_G0033486	protein coding gene	Chr8:26045951-26614359 (-)
C3H/HeJ	MGP_C3HHeJ_G0033200	protein coding gene	Chr8:26991800-27583452 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034003	protein coding gene	Chr8:27984953-28590619 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030953	protein coding gene	Chr8:22980044-23520778 (-)
CAST/EiJ	MGP_CASTEiJ_G0032526	protein coding gene	Chr8:26438381-27006551 (-)
CBA/J	MGP_CBAJ_G0033177	protein coding gene	Chr8:29115181-29729292 (-)
DBA/2J	MGP_DBA2J_G0033330	protein coding gene	Chr8:25867495-26431786 (-)
FVB/NJ	MGP_FVBNJ_G0033274	protein coding gene	Chr8:25687664-26265000 (-)
LP/J	MGP_LPJ_G0033420	protein coding gene	Chr8:26874122-27469614 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033317	protein coding gene	Chr8:28564252-29171621 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034022	protein coding gene	Chr8:26709731-27307553 (-)
PWK/PhJ	MGP_PWKPhJ_G0032238	protein coding gene	Chr8:25464777-26023891 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032071	protein coding gene	Chr8:26035489-26613935 (-)
WSB/EiJ	MGP_WSBEiJ_G0032642	protein coding gene	Chr8:26883367-27467948 (-)

Human Ortholog

UNC5D, unc-5 netrin receptor D

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNC5D, unc-5 netrin receptor D
Synonyms

PRO34692, Unc5h4
Links

HGNC:18634

NCBI Gene ID: 137970

neXtProt AC: NX_Q6UXZ4

UniProt: Q6UXZ4
Chr Location

8p12; chr8:35235475-35796550 (+) GRCh38

MGI Vertebrate Homology

Unc5d stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: UNC5D
Gene Tree

Unc5d

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available

Mice exhibit impaired induced growth cone collapse response and accelerated radial migration of cortical neurons.

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All GO Annotations

14
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1117
Tissues

175
cDNA Data

13
Literature Summary

43

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase unc5d

ZFIN unc5da, unc5db

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All Sequences

70
RefSeq

24
UniProt

7
CCDS

CCDS40314.1, CCDS85521.1, CCDS85522.1, CCDS85523.1, CCDS85524.1

Ensembl

ENSMUSG00000063626 (Evidence)
NCBI Gene

210801

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063626	Ensembl Gene Model \| MGI Sequence Detail	572920	C57BL/6J	± kb
transcript	ENSMUST00000168630	Ensembl \| MGI Sequence Detail	9220	Not Applicable
polypeptide	ENSMUSP00000128521	Ensembl \| MGI Sequence Detail	956	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017097 netrin receptor UNC5D

(term hierarchy)
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR037936 Netrin receptor UNC5

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR042058 UNC5D, Death domain

IPR033772 UPA domain

IPR000906 ZU5 domain

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All nucleic 19

cDNA 14

Primer pair 4

Other 1

Microarray probesets 2

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MGI:2444819

Summaries

All 74

Developmental Gene Expression 43

Gene Ontology 10

Phenotypes 9
Earliest

J:79319 Engelkamp D, Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. Mech Dev. 2002 Oct;118(1-2):191
Latest

J:339867 Prigge CL, et al., Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling. Dev Cell. 2023 Aug 3;

TSS for Unc5d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80810	Chr8:29709655-29709668 (-)	2 bp
Tssr80809	Chr8:29709605-29709651 (-)	36 bp
Tssr80808	Chr8:29640571-29640615 (-)	69,071 bp
Tssr80807	Chr8:29319459-29319464 (-)	390,202 bp
Tssr80806	Chr8:29141198-29141202 (-)	568,464 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23