Plekhg3 MGI Mouse Gene Detail - MGI:2388284 - pleckstrin homology domain containing, family G (with RhoGef domain) member 3

Symbol

Plekhg3
Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms

MGC40768

Feature Type

protein coding gene
IDs

MGI:2388284
NCBI Gene: 263406
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:76580330-76627265 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 33.73 cM
Mapping Data

1 experiment

SNPs within 2kb

1476 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388284	protein coding gene	Chr12:76577665-76627265 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019861	protein coding gene	Chr12:76666031-76711990 (+)
A/J	MGP_AJ_G0019819	protein coding gene	Chr12:73740531-73788375 (+)
AKR/J	MGP_AKRJ_G0019794	protein coding gene	Chr12:75979695-76026612 (+)
BALB/cJ	MGP_BALBcJ_G0019798	protein coding gene	Chr12:74214069-74259395 (+)
C3H/HeJ	MGP_C3HHeJ_G0019604	protein coding gene	Chr12:76436564-76483091 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020250	protein coding gene	Chr12:79002506-79050180 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017868	protein coding gene	Chr12:71083119-71127823 (+)
CAST/EiJ	MGP_CASTEiJ_G0019155	protein coding gene	Chr12:71257518-71305802 (+)
CBA/J	MGP_CBAJ_G0019574	protein coding gene	Chr12:82057676-82112009 (+)
DBA/2J	MGP_DBA2J_G0019690	protein coding gene	Chr12:73589401-73635035 (+)
FVB/NJ	MGP_FVBNJ_G0019677	protein coding gene	Chr12:72431163-72476876 (+)
LP/J	MGP_LPJ_G0019762	protein coding gene	Chr12:76632637-76680090 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019716	protein coding gene	Chr12:85077817-85128967 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020286	protein coding gene	Chr12:75464708-75512564 (+)
PWK/PhJ	MGP_PWKPhJ_G0018921	protein coding gene	Chr12:67968402-68014746 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018715	protein coding gene	Chr12:69973861-70018677 (+)
WSB/EiJ	MGP_WSBEiJ_G0019207	protein coding gene	Chr12:76069171-76118264 (+)

Human Ortholog

PLEKHG3, pleckstrin homology and RhoGEF domain containing G3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLEKHG3, pleckstrin homology and RhoGEF domain containing G3
Synonyms

ARHGEF43, KIAA0599
Links

HGNC:20364

NCBI Gene ID: 26030

UniProt: A1L390
Chr Location

14q23.3; chr14:64704102-64750249 (+) GRCh38

MGI Vertebrate Homology

Plekhg3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PLEKHG3
Gene Tree

Plekhg3

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

28
Targeted

4
Genomic Mutations

1 involving Plekhg3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

84 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

35
cDNA Data

47
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plekhg3

less

All Sequences

73
RefSeq

24
UniProt

4
CCDS

CCDS25994.1

Ensembl

ENSMUSG00000052609 (Evidence)
NCBI Gene

263406

			Length	Strain/Species	Flank
genomic	263406	NCBI Gene Model \| MGI Sequence Detail	46936	C57BL/6J	± kb
transcript	NM_153804	RefSeq \| MGI Sequence Detail	6411	C57BL/6
polypeptide	Q4VAC9	UniProt \| EBI \| MGI Sequence Detail	1341	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000031320 pleckstrin homology domain-containing family G member 3

(term hierarchy)
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR011993 PH-like domain superfamily

IPR043324 PKHG1/2/3, pleckstrin homology (PH) domain

IPR001849 Pleckstrin homology domain
GlyGen

Q4VAC9 1 site

less

All nucleic 47

cDNA 47

Microarray probesets 1

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 15
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plekhg3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113976	Chr12:76580314-76580371 (+)	13 bp
Tssr113977	Chr12:76580387-76580399 (+)	63 bp
Tssr113978	Chr12:76580405-76580420 (+)	83 bp
Tssr113979	Chr12:76593850-76593862 (+)	13,526 bp
Tssr113980	Chr12:76618297-76618313 (+)	37,975 bp
Tssr113981	Chr12:76618318-76618341 (+)	38,000 bp
Tssr113982	Chr12:76619878-76619889 (+)	39,554 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24