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Acap1 Gene Detail
Summary
  • Symbol
    Acap1
  • Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
  • Synonyms
    Centb1, MGC:25782, MGC:47358
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388270
    NCBI Gene: 216859
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69772393-69786365 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388270
 protein coding gene Chr11:69772393-69786390 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018565
 protein coding gene Chr11:70366116-70385938 (-)
A/J MGP_AJ_G0018533
 protein coding gene Chr11:67702392-67722429 (-)
AKR/J MGP_AKRJ_G0018502
 protein coding gene Chr11:69725702-69744780 (-)
BALB/cJ MGP_BALBcJ_G0018505
 protein coding gene Chr11:68031556-68053772 (-)
C3H/HeJ MGP_C3HHeJ_G0018318
 protein coding gene Chr11:69758264-69781340 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018956
 protein coding gene Chr11:72491822-72513089 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016601
 protein coding gene Chr11:64629904-64643984 (-)
CAST/EiJ MGP_CASTEiJ_G0017873
 protein coding gene Chr11:70002811-70020616 (-)
CBA/J MGP_CBAJ_G0018291
 protein coding gene Chr11:75729838-75761596 (-)
DBA/2J MGP_DBA2J_G0018400
 protein coding gene Chr11:67287569-67308330 (-)
FVB/NJ MGP_FVBNJ_G0018390
 protein coding gene Chr11:66929570-66948365 (-)
LP/J MGP_LPJ_G0018470
 protein coding gene Chr11:70940655-70964340 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018413
 protein coding gene Chr11:76338338-76357181 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018998
 protein coding gene Chr11:69984263-70015229 (-)
PWK/PhJ MGP_PWKPhJ_G0017647
 protein coding gene Chr11:67938249-67957912 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017437
 protein coding gene Chr11:69802270-69823150 (-)
WSB/EiJ MGP_WSBEiJ_G0017927
 protein coding gene Chr11:69658736-69677819 (-)



Homology
more
  • Human Ortholog
    ACAP1, ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACAP1, ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
  • Synonyms
    CENTB1
  • Links
    NCBI Gene ID: 9744
    neXtProt AC: NX_Q15027
    UniProt: Q15027

  • Chr Location
    17p13.1; chr17:7336529-7351477 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    44
  • cDNA Data
    28
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001588 Ensembl Gene Model | MGI Sequence Detail 13973 C57BL/6J ±  kb
    transcript ENSMUST00000001631 Ensembl | MGI Sequence Detail 2482 Not Applicable  
    polypeptide ENSMUSP00000001631 Ensembl | MGI Sequence Detail 740 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:276877 Qu X, et al., Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/19/2023
    MGI 6.22     		The Jackson Laboratory