About   Help   FAQ
Catsper2 Gene Detail
Summary
  • Symbol
    Catsper2
  • Name
    cation channel, sperm associated 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387404
    NCBI Gene: 212670
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121223112-121244273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387404
 protein coding gene Chr2:121222109-121245082 (-)
129S1/SvImJ ENSMUSG00200044540
 protein coding gene Chr2:118153219-118174476 (-)
A/J ENSMUSG00195023655
 protein coding gene Chr2:118194793-118216053 (-)
AKR/J ENSMUSG00220041503
 protein coding gene Chr2:118117781-118139040 (-)
BALB/cJ ENSMUSG00180043538
 protein coding gene Chr2:117995428-118016690 (-)
C3H/HeJ ENSMUSG00175023076
 protein coding gene Chr2:118469542-118490803 (-)
C57BL/6NJ ENSMUSG00215017355
 protein coding gene Chr2:118143171-118161102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024191
 protein coding gene Chr2:114251692-114273395 (-)
CAST/EiJ ENSTCUG00005016362
 protein coding gene Chr2:117404450-117425745 (-)
CBA/J ENSMUSG00210007326
 protein coding gene Chr2:118310413-118331674 (-)
DBA/2J ENSMUSG00185046718
 protein coding gene Chr2:117992725-118013986 (-)
FVB/NJ ENSMUSG00205023623
 protein coding gene Chr2:117218196-117239455 (-)
JF1/MsJ ENSUMUG00000008352
 protein coding gene Chr2:117891343-117909277 (-)
LP/J ENSMUSG00230022817
 protein coding gene Chr2:119812821-119834076 (-)
NOD/ShiLtJ ENSMUSG00190027486
 protein coding gene Chr2:118238534-118259731 (-)
NZO/HlLtJ ENSMUSG00225002678
 protein coding gene Chr2:127716026-127738893 (-)
PWK/PhJ ENSLUMG00010045065
 protein coding gene Chr2:117781483-117803093 (-)
SPRET/EiJ ENSMSPG00010042665
 protein coding gene Chr2:120224664-120243660 (-)
WSB/EiJ ENSIUOG00005021906
 protein coding gene Chr2:117966266-117987508 (-)



Homology
more
  • Human Ortholog
    CATSPER2, cation channel sperm associated 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CATSPER2, cation channel sperm associated 2
  • Links
    NCBI Gene ID: 117155
    UniProt: Q96P56

  • Chr Location
    15q15.3; chr15:43628503-43668118 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mice are infertile due to a sperm motility defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033486 Ensembl Gene Model | MGI Sequence Detail 21162 C57BL/6J ±  kb
    transcript ENSMUST00000038073 Ensembl | MGI Sequence Detail 2247 Not Applicable  
    polypeptide ENSMUSP00000037222 Ensembl | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:314092 Lin S, et al., Structure of a mammalian sperm cation channel complex. Nature. 2021 Jul;595(7869):746-750
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory