Mettl25b MGI Mouse Gene Detail - MGI:2387197

Symbol

Mettl25b
Name

methyltransferase like 25B
Synonyms

BC023814, MGC:38548, Rrnad1

Feature Type

protein coding gene
IDs

MGI:2387197
NCBI Gene: 229503
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:87829908-87838024 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.78 cM
Mapping Data

2 experiments

SNPs within 2kb

199 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387197	protein coding gene	Chr3:87829908-87838337 (-)
129S1/SvImJ	ENSMUSG00200039145	protein coding gene	Chr3:84684728-84692710 (-)
A/J	ENSMUSG00195051360	protein coding gene	Chr3:84706767-84714531 (-)
AKR/J	ENSMUSG00220047201	protein coding gene	Chr3:84654741-84662507 (-)
BALB/cJ	ENSMUSG00180043278	protein coding gene	Chr3:84824358-84832124 (-)
C3H/HeJ	ENSMUSG00175045432	protein coding gene	Chr3:84634497-84642261 (-)
C57BL/6NJ	ENSMUSG00215047576	protein coding gene	Chr3:85072450-85080432 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025146	protein coding gene	Chr3:80687227-80695337 (-)
CAST/EiJ	ENSTCUG00005044813	protein coding gene	Chr3:84161943-84169679 (-)
CBA/J	ENSMUSG00210042975	protein coding gene	Chr3:84777507-84785271 (-)
DBA/2J	ENSMUSG00185049435	protein coding gene	Chr3:84913055-84920821 (-)
FVB/NJ	ENSMUSG00205043854	protein coding gene	Chr3:83701941-83709705 (-)
JF1/MsJ	ENSUMUG00000007974	protein coding gene	Chr3:84455611-84463819 (-)
LP/J	ENSMUSG00230030186	protein coding gene	Chr3:86906169-86914151 (-)
NOD/ShiLtJ	ENSMUSG00190048996	protein coding gene	Chr3:85154160-85161924 (-)
NZO/HlLtJ	ENSMUSG00225005535	protein coding gene	Chr3:89659969-89667733 (-)
PWK/PhJ	ENSLUMG00010039430	protein coding gene	Chr3:84544157-84551926 (-)
SPRET/EiJ	ENSMSPG00010046853	protein coding gene	Chr3:85374954-85382398 (-)
WSB/EiJ	ENSIUOG00005044265	protein coding gene	Chr3:85150875-85158855 (-)

Human Ortholog

METTL25B, methyltransferase like 25B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

METTL25B, methyltransferase like 25B
Synonyms

C1orf66, CGI-41, RRNAD1
Links

HGNC:24273

NCBI Gene ID: 51093

UniProt: Q96FB5
Chr Location

1q23.1; chr1:156728442-156736960 (+) GRCh38

MGI Vertebrate Homology

Mettl25b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: METTL25B
Gene Tree

Mettl25b

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References

1 with disease annotations

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Phenotype Summary

7 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Mettl25b
Incidental Mutations

CvDC
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

12

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mettl25b

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All Sequences

87
RefSeq

24
UniProt

5
CCDS

CCDS17458.1

Ensembl

ENSMUSG00000004896 (Evidence)
NCBI Gene

229503

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004896	Ensembl Gene Model \| MGI Sequence Detail	8117	C57BL/6J	± kb
transcript	ENSMUST00000005016	Ensembl \| MGI Sequence Detail	2492	Not Applicable
polypeptide	ENSMUSP00000005016	Ensembl \| MGI Sequence Detail	475	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000032734 methyltransferase-like protein 25B

(term hierarchy)
InterPro Domains

IPR025714 Methyltransferase domain

IPR052220 Methyltransferase-like protein 25

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

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All nucleic 12

cDNA 12

Microarray probesets 3

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MGI:7461493

Summaries

All 29

Diseases 1

Gene Ontology 1

Phenotypes 7
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Mettl25b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33964	Chr3:87837428-87837489 (-)	565 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24