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Cyb5r4 Gene Detail
Summary
  • Symbol
    Cyb5r4
  • Name
    cytochrome b5 reductase 4
  • Synonyms
    2810034J18Rik, b5/b5r, B5+B5R, Ncb5or
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386848
    NCBI Gene: 266690
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:86904082-86959827 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386848
 protein coding gene Chr9:86904067-86959827 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035102
 protein coding gene Chr9:87890342-87949382 (+)
A/J MGP_AJ_G0035083
 protein coding gene Chr9:84809760-84862472 (+)
AKR/J MGP_AKRJ_G0035011
 protein coding gene Chr9:86835326-86889523 (+)
BALB/cJ MGP_BALBcJ_G0035071
 protein coding gene Chr9:84455315-84504761 (+)
C3H/HeJ MGP_C3HHeJ_G0034783
 protein coding gene Chr9:87286612-87344718 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035595
 protein coding gene Chr9:90240266-90308247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032502
 protein coding gene Chr9:83587697-83639522 (+)
CAST/EiJ MGP_CASTEiJ_G0034101
 protein coding gene Chr9:87749100-87807615 (+)
CBA/J MGP_CBAJ_G0034756
 protein coding gene Chr9:93392572-93455126 (+)
DBA/2J MGP_DBA2J_G0034914
 protein coding gene Chr9:84366430-84421159 (+)
FVB/NJ MGP_FVBNJ_G0034857
 protein coding gene Chr9:83454577-83509163 (+)
LP/J MGP_LPJ_G0034995
 protein coding gene Chr9:88107440-88168889 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034899
 protein coding gene Chr9:95057344-95121250 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035615
 protein coding gene Chr9:86936105-86999060 (+)
PWK/PhJ MGP_PWKPhJ_G0033805
 protein coding gene Chr9:84537993-84593326 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033641
 protein coding gene Chr9:87141726-87192466 (+)
WSB/EiJ MGP_WSBEiJ_G0034218
 protein coding gene Chr9:86974999-87031876 (+)



Homology
more
  • Human Ortholog
    CYB5R4, cytochrome b5 reductase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYB5R4, cytochrome b5 reductase 4
  • Synonyms
    cb5/cb5R, dJ676J13.1, NCB5OR
  • Links
    NCBI Gene ID: 51167
    neXtProt AC: NX_Q7L1T6
    UniProt: Q7L1T6

  • Chr Location
    6q14.2; chr6:83859656-83967423 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cyb5r4 mouse models; 1 with human CYB5R4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit defects in glucose homeostasis and pancreatic abnormalities consistent with symptoms of diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    11
  • cDNA Data
    52
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 266690 NCBI Gene Model | MGI Sequence Detail 55746 C57BL/6J ±  kb
    transcript NM_024195 RefSeq | MGI Sequence Detail 2653 C57BL/6  
    polypeptide Q3TDX8 UniProt | EBI | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006083 cytochrome b5 reductase 4
      (term hierarchy)
    • EC
      1.6.2.2
    • InterPro Domains
      IPR007052 CS domain
      IPR018506 Cytochrome b5, heme-binding site
      IPR001199 Cytochrome b5-like heme/steroid binding domain
      IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily
      IPR037908 Cytochrome b5 reductase 4, p23 domain
      IPR017927 FAD-binding domain, ferredoxin reductase-type
      IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
      IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
      IPR008978 HSP20-like chaperone
      IPR001834 NADH:cytochrome b5 reductase-like
      IPR001433 Oxidoreductase FAD/NAD(P)-binding
      IPR017938 Riboflavin synthase-like beta-barrel
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 53

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914464, MGI:2143407
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:59088 Zhu H, et al., Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14742-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory