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Mfrp Gene Detail
Summary
  • Symbol
    Mfrp
  • Name
    membrane frizzled-related protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385957
    NCBI Gene: 259172
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44013067-44020484 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385957
 protein coding gene Chr9:44013026-44020484 (+)
129S1/SvImJ ENSMUSG00200018135
 protein coding gene Chr9:41101917-41107652 (+)
A/J ENSMUSG00195021140
 protein coding gene Chr9:40846036-40851768 (+)
AKR/J ENSMUSG00220036319
 protein coding gene Chr9:40943570-40949305 (+)
BALB/cJ ENSMUSG00180023303
 protein coding gene Chr9:40957746-40963478 (+)
C3H/HeJ ENSMUSG00175013290
 protein coding gene Chr9:40969447-40975179 (+)
C57BL/6NJ ENSMUSG00215025277
 protein coding gene Chr9:40933250-40938982 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032098
 protein coding gene Chr9:40978067-40985515 (+)
CAST/EiJ ENSTCUG00005015203
 protein coding gene Chr9:40931978-40937701 (+)
CBA/J ENSMUSG00210015791
 protein coding gene Chr9:41016818-41022542 (+)
DBA/2J ENSMUSG00185010724
 protein coding gene Chr9:41084396-41090128 (+)
FVB/NJ ENSMUSG00205018712
 protein coding gene Chr9:41343158-41348890 (+)
JF1/MsJ ENSUMUG00000008645
 protein coding gene Chr9:41141456-41147191 (+)
LP/J ENSMUSG00230038972
 protein coding gene Chr9:41392412-41398147 (+)
NOD/ShiLtJ ENSMUSG00190021748
 protein coding gene Chr9:41163376-41169108 (+)
NZO/HlLtJ ENSMUSG00225041793
 protein coding gene Chr9:41346901-41352633 (+)
PWK/PhJ ENSLUMG00010019026
 protein coding gene Chr9:41096282-41101993 (+)
SPRET/EiJ ENSMSPG00010009627
 protein coding gene Chr9:41865524-41871274 (+)
WSB/EiJ ENSIUOG00005020102
 protein coding gene Chr9:40580171-40585903 (+)



Homology
more
  • Human Ortholog
    MFRP, membrane frizzled-related protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFRP, membrane frizzled-related protein
  • Synonyms
    CTRP5, MCOP5, NNO2, RD6
  • Links
    NCBI Gene ID: 83552
    UniProt: Q9BY79

  • Chr Location
    11q23.3; chr11:119338942-119346705 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mfrp mouse models; 5 with human C1QTNF5,MFRP associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
 View 1 model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations produce mice having small, white retinal spots and progressive photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    2
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 259172 NCBI Gene Model | MGI Sequence Detail 7418 C57BL/6J ±  kb
    transcript NM_147126 RefSeq | MGI Sequence Detail 4292 ZRU/MplStud  
    polypeptide Q8K480 UniProt | EBI | MGI Sequence Detail 584 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1
      Antibodies 1
    Other
    Accession IDs
    less
    MGI:1888693
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 5
      Phenotypes 24
    • Earliest
      J:64087 Hawes NL, et al., Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3149-57
    • Latest
      J:366842 Geilenkeuser J, et al., Engineered nucleocytosolic vehicles for loading of programmable editors. Cell. 2025 May 15;188(10):2637-2655.e31
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory