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Rad9b Gene Detail
Summary
  • Symbol
    Rad9b
  • Name
    RAD9 checkpoint clamp component B
  • Synonyms
    A630082N15Rik, MGC:28469
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385231
    NCBI Gene: 231724
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122461286-122492296 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385231
 protein coding gene Chr5:122461286-122492297 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030047
 protein coding gene Chr5:125954219-125989554 (-)
A/J MGP_AJ_G0030012
 protein coding gene Chr5:120737690-120769199 (-)
AKR/J MGP_AKRJ_G0029948
 protein coding gene Chr5:124622804-124651599 (-)
BALB/cJ MGP_BALBcJ_G0030023
 protein coding gene Chr5:122084755-122115656 (-)
C3H/HeJ MGP_C3HHeJ_G0029740
 protein coding gene Chr5:125236767-125269588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030476
 protein coding gene Chr5:130789406-130823827 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027702
 protein coding gene Chr5:115343617-115375192 (-)
CAST/EiJ MGP_CASTEiJ_G0029149
 protein coding gene Chr5:124334736-124368703 (-)
CBA/J MGP_CBAJ_G0029710
 protein coding gene Chr5:135925473-135960843 (-)
DBA/2J MGP_DBA2J_G0029860
 protein coding gene Chr5:120795201-120824779 (-)
FVB/NJ MGP_FVBNJ_G0029816
 protein coding gene Chr5:119778432-119812056 (-)
LP/J MGP_LPJ_G0029949
 protein coding gene Chr5:126496575-126532461 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029847
 protein coding gene Chr5:139676308-139708985 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030517
 protein coding gene Chr5:124215757-124250224 (-)
PWK/PhJ MGP_PWKPhJ_G0028863
 protein coding gene Chr5:119561151-119595788 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028700
 protein coding gene Chr5:121912007-121947387 (-)
WSB/EiJ MGP_WSBEiJ_G0029224
 protein coding gene Chr5:124881508-124913476 (-)



Homology
more
  • Human Ortholog
    RAD9B, RAD9 checkpoint clamp component B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD9B, RAD9 checkpoint clamp component B
  • Links
    NCBI Gene ID: 144715
    neXtProt AC: NX_Q6WBX8
    UniProt: Q6WBX8

  • Chr Location
    12q24.11; chr12:110501655-110533556 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality, decreased forebrain and somite cell proliferation, and increased cellular sensitivity to gamma irradiation and mitomycin C. Mice heterozygous for a knock-out allele exhibit reduced embryonic, fetal, and early postnatal survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038569 Ensembl Gene Model | MGI Sequence Detail 31011 C57BL/6J ±  kb
    transcript ENSMUST00000049009 Ensembl | MGI Sequence Detail 1631 Not Applicable  
    polypeptide ENSMUSP00000036177 Ensembl | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443896
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:233532 Scekic-Zahirovic J, et al., Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J. 2016 May 17;35(10):1077-97
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory