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Rap1gds1 Gene Detail
Summary
  • Symbol
    Rap1gds1
  • Name
    RAP1, GTP-GDP dissociation stimulator 1
  • Synonyms
    GDS1, MGC:18981
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385189
    NCBI Gene: 229877
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138631663-138780962 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4842 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385189
 protein coding gene Chr3:138631662-138781163 (-)
129S1/SvImJ ENSMUSG00200002801
 protein coding gene Chr3:135416655-135569689 (-)
A/J ENSMUSG00195003940
 protein coding gene Chr3:135519777-135669640 (-)
AKR/J ENSMUSG00220003342
 protein coding gene Chr3:133970507-134120370 (-)
BALB/cJ ENSMUSG00180011385
 protein coding gene Chr3:135433828-135583695 (-)
C3H/HeJ ENSMUSG00175018008
 protein coding gene Chr3:135037049-135186909 (-)
C57BL/6NJ ENSMUSG00215020749
 protein coding gene Chr3:135791483-135940803 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025686
 protein coding gene Chr3:132386002-132537655 (-)
CAST/EiJ ENSTCUG00005028864
 protein coding gene Chr3:136151429-136308375 (-)
CBA/J ENSMUSG00210031387
 protein coding gene Chr3:135653134-135806262 (-)
DBA/2J ENSMUSG00185003504
 protein coding gene Chr3:136262871-136412970 (-)
FVB/NJ ENSMUSG00205016819
 protein coding gene Chr3:134572091-134721964 (-)
JF1/MsJ ENSUMUG00000002623
 protein coding gene Chr3:135071555-135219387 (-)
LP/J ENSMUSG00230002216
 protein coding gene Chr3:138230374-138383405 (-)
NOD/ShiLtJ ENSMUSG00190004515
 protein coding gene Chr3:136652032-136805076 (-)
NZO/HlLtJ ENSMUSG00225005166
 protein coding gene Chr3:140698307-140851336 (-)
PWK/PhJ ENSLUMG00010020390
 protein coding gene Chr3:134967237-135116871 (-)
SPRET/EiJ ENSMSPG00010013851
 protein coding gene Chr3:136143738-136288070 (-)
WSB/EiJ ENSIUOG00005018533
 protein coding gene Chr3:135828150-135981291 (-)



Homology
more
  • Human Ortholog
    RAP1GDS1, Rap1 GTPase-GDP dissociation stimulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAP1GDS1, Rap1 GTPase-GDP dissociation stimulator 1
  • Synonyms
    GDS1, SmgGDS
  • Links
    NCBI Gene ID: 5910
    UniProt: P52306

  • Chr Location
    4q23; chr4:98261243-98443864 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    659
  • Tissues
    23
  • cDNA Data
    130
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028149 Ensembl Gene Model | MGI Sequence Detail 149300 C57BL/6J ±  kb
    transcript ENSMUST00000098574 Ensembl | MGI Sequence Detail 3669 Not Applicable  
    polypeptide ENSMUSP00000096173 Ensembl | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 132
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:62244 Takakura A, et al., Involvement of a small GTP-binding protein (G protein) regulator, small G protein GDP dissociation stimulator, in antiapoptotic cell survival signaling. Mol Biol Cell. 2000 May;11(5):1875-86
    • Latest
      J:390416 Wang T, et al., Estradiol-mediated small GTP-binding protein GDP dissociation stimulator induction contributes to sex differences in resilience to ferroptosis in takotsubo syndrome. Redox Biol. 2023 Dec;68:102961
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory