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Mettl8 Gene Detail
Summary
  • Symbol
    Mettl8
  • Name
    methyltransferase 8, methylcytidine
  • Synonyms
    MGC:67805, MGC:7995, TIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385142
    NCBI Gene: 228019
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70794905-70885927 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2726 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385142
 protein coding gene Chr2:70794902-70886729 (-)
129S1/SvImJ ENSMUSG00200035735
 protein coding gene Chr2:67855412-67942225 (-)
A/J ENSMUSG00195020833
 protein coding gene Chr2:68005567-68092751 (-)
AKR/J ENSMUSG00220036865
 protein coding gene Chr2:67970299-68057497 (-)
BALB/cJ ENSMUSG00180040684
 protein coding gene Chr2:67953536-68040719 (-)
C3H/HeJ ENSMUSG00175036413
 protein coding gene Chr2:68072968-68160163 (-)
C57BL/6NJ ENSMUSG00215017859
 protein coding gene Chr2:67891800-67978997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023639
 protein coding gene Chr2:65506968-65596400 (-)
CAST/EiJ ENSTCUG00005008777
 protein coding gene Chr2:67377654-67464119 (-)
CBA/J ENSMUSG00210036094
 protein coding gene Chr2:68112779-68199950 (-)
DBA/2J ENSMUSG00185038366
 protein coding gene Chr2:67948441-68035612 (-)
FVB/NJ ENSMUSG00205020624
 protein coding gene Chr2:67416047-67503225 (-)
JF1/MsJ ENSUMUG00000004061
 protein coding gene Chr2:67614945-67702126 (-)
LP/J ENSMUSG00230021538
 protein coding gene Chr2:69753783-69840960 (-)
NOD/ShiLtJ ENSMUSG00190031807
 protein coding gene Chr2:68038729-68125887 (-)
NZO/HlLtJ ENSMUSG00225014858
 protein coding gene Chr2:77496092-77583274 (-)
PWK/PhJ ENSLUMG00010030402
 protein coding gene Chr2:67835815-67922759 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005018412
 protein coding gene Chr2:68085679-68172808 (-)



Homology
more
  • Human Ortholog
    METTL8, methyltransferase 8, tRNA N3-cytidine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL8, methyltransferase 8, tRNA N3-cytidine
  • Synonyms
    TIP
  • Links
    NCBI Gene ID: 79828
    UniProt: Q9H825

  • Chr Location
    2q31.1; chr2:171315746-171434802 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced 3-methylcytidine (m3C) methyltransferases modification of mRNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    16
  • cDNA Data
    5
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041975 Ensembl Gene Model | MGI Sequence Detail 91023 C57BL/6J ±  kb
transcript ENSMUST00000112186 Ensembl | MGI Sequence Detail 2347 Not Applicable  
polypeptide ENSMUSP00000107804 Ensembl | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010354 tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR013216 Methyltransferase type 11
    IPR013217 Methyltransferase type 12
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR026113 tRNA N(3)-methylcytidine methyltransferase METTL2/6/8-like
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345299 Wang Y, et al., Tax1 binding protein 3 regulates osteogenic and adipogenic differentiation through inactivating Wnt/beta-catenin signalling. J Cell Mol Med. 2023 Apr;27(7):950-961
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory