About   Help   FAQ
Zng1 Gene Detail
Summary
  • Symbol
    Zng1
  • Name
    Zn regulated GTPase metalloprotein activator 1
  • Synonyms
    Cbwd1, MGC:28027, MGC:59411, Zng1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385089
    NCBI Gene: 226043
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:24897280-24938974 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 19.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1098 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385089
 protein coding gene Chr19:24897280-24939024 (-)
129S1/SvImJ ENSMUSG00200020318
 protein coding gene Chr19:21626573-21668267 (-)
A/J ENSMUSG00195034693
 protein coding gene Chr19:21756941-21799156 (-)
AKR/J ENSMUSG00220019092
 protein coding gene Chr19:21771086-21813285 (-)
BALB/cJ ENSMUSG00180013454
 protein coding gene Chr19:22097199-22139218 (-)
C3H/HeJ ENSMUSG00175024101
 protein coding gene Chr19:21468726-21510756 (-)
C57BL/6NJ ENSMUSG00215025587
 protein coding gene Chr19:21507958-21549653 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022835
 protein coding gene Chr19:22057997-22099580 (-)
CAST/EiJ ENSTCUG00005017741
 protein coding gene Chr19:21362394-21404327 (-)
CBA/J ENSMUSG00210014597
 protein coding gene Chr19:21699775-21741796 (-)
DBA/2J ENSMUSG00185024157
 protein coding gene Chr19:22086359-22128385 (-)
FVB/NJ ENSMUSG00205010047
 protein coding gene Chr19:21522906-21565135 (-)
JF1/MsJ ENSUMUG00000019027
 protein coding gene Chr19:22297547-22339407 (-)
LP/J ENSMUSG00230025362
 protein coding gene Chr19:22936108-22977800 (-)
NOD/ShiLtJ ENSMUSG00190019528
 protein coding gene Chr19:21478900-21520593 (-)
NZO/HlLtJ ENSMUSG00225033782
 protein coding gene Chr19:26686991-26728682 (-)
PWK/PhJ ENSLUMG00010031106
 protein coding gene Chr19:21640704-21682584 (-)
SPRET/EiJ ENSMSPG00010033904
 protein coding gene Chr19:21660208-21702186 (-)
WSB/EiJ ENSIUOG00005026137
 protein coding gene Chr19:21177937-21219532 (-)



Homology
more
  • Human Ortholog
    ZNG1A, Zn regulated GTPase metalloprotein activator 1A
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNG1A, Zn regulated GTPase metalloprotein activator 1A
  • Synonyms
    CBWD1, COBP
  • Links
    NCBI Gene ID: 55871
    UniProt: Q9BRT8

  • Chr Location
    9p24.3; chr9:119288-179147 (-)  GRCh38
  • Human Ortholog
    ZNG1B, Zn regulated GTPase metalloprotein activator 1B
  • Synonyms
    CBWD2
  • Links
    NCBI Gene ID: 150472
    UniProt: Q8IUF1

  • Chr Location
    2q14.1; chr2:113437691-113496204 (+)  GRCh38
  • Human Ortholog
    ZNG1C, Zn regulated GTPase metalloprotein activator 1C
  • Synonyms
    bA561O23.1, CBWD3
  • Links
    NCBI Gene ID: 445571
    UniProt: Q5JTY5

  • Chr Location
    9q21.11; chr9:68232003-68300036 (+)  GRCh38
  • Human Ortholog
    ZNG1E, Zn regulated GTPase metalloprotein activator 1E
  • Synonyms
    CBWD3, CBWD5, DC36
  • Links
    NCBI Gene ID: 220869
    UniProt: Q5RIA9

  • Chr Location
    9q21.11; chr9:65652979-65735823 (+)  GRCh38
  • Human Ortholog
    ZNG1F, Zn regulated GTPase metalloprotein activator 1F
  • Synonyms
    CBWD6, CBWD7
  • Links
    NCBI Gene ID: 644019
    UniProt: Q4V339

  • Chr Location
    9p11.2
Human Diseases
more
  • Diseases
    1 with Zng1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hydronephrosis, hydroureter, and double ureter, all CAKUT phentoypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    6
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024878 Ensembl Gene Model | MGI Sequence Detail 41695 C57BL/6J ±  kb
    transcript ENSMUST00000025815 Ensembl | MGI Sequence Detail 1929 Not Applicable  
    polypeptide ENSMUSP00000025815 Ensembl | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147682, MGI:7438389
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:325966 Weiss A, et al., Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Cell. 2022 Jun 9;185(12):2148-2163.e27
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory