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Fermt2 Gene Detail
Summary
  • Symbol
    Fermt2
  • Name
    fermitin family member 2
  • Synonyms
    Kindlin-2, Mig2, Plekhc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385001
    NCBI Gene: 218952
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45696252-45767575 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385001
 protein coding gene Chr14:45696249-45767767 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021209
 protein coding gene Chr14:39087551-39162769 (-)
A/J MGP_AJ_G0021156
 protein coding gene Chr14:37942650-38014392 (-)
AKR/J MGP_AKRJ_G0021134
 protein coding gene Chr14:39419799-39499692 (-)
BALB/cJ MGP_BALBcJ_G0021160
 protein coding gene Chr14:37981134-38054192 (-)
C3H/HeJ MGP_C3HHeJ_G0020943
 protein coding gene Chr14:39223087-39297861 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021594
 protein coding gene Chr14:40788327-40873481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019153
 protein coding gene Chr14:37349842-37420789 (-)
CAST/EiJ MGP_CASTEiJ_G0020468
 protein coding gene Chr14:36339974-36416278 (-)
CBA/J MGP_CBAJ_G0020909
 protein coding gene Chr14:42100467-42176228 (-)
DBA/2J MGP_DBA2J_G0021032
 protein coding gene Chr14:37849218-37921257 (-)
FVB/NJ MGP_FVBNJ_G0021017
 protein coding gene Chr14:37606777-37678246 (-)
LP/J MGP_LPJ_G0021102
 protein coding gene Chr14:39372611-39444586 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021042
 protein coding gene Chr14:41483676-41561684 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021627
 protein coding gene Chr14:38959573-39032036 (-)
PWK/PhJ MGP_PWKPhJ_G0020217
 protein coding gene Chr14:34718263-34792114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020041
 protein coding gene Chr14:35127149-35188386 (-)
WSB/EiJ MGP_WSBEiJ_G0020524
 protein coding gene Chr14:39065099-39141868 (-)



Homology
more
  • Human Ortholog
    FERMT2, FERM domain containing kindlin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FERMT2, FERM domain containing kindlin 2
  • Synonyms
    KIND2, mig-2, MIG2, PLEKHC1, UNC112, UNC112B
  • Links
    NCBI Gene ID: 10979
    neXtProt AC: NX_Q96AC1
    UniProt: Q96AC1

  • Chr Location
    14q22.1; chr14:52857268-52952435 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 6 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are embryonic lethal at or before E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    51
  • cDNA Data
    154
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037712 Ensembl Gene Model | MGI Sequence Detail 71324 C57BL/6J ±  kb
    transcript ENSMUST00000045905 Ensembl | MGI Sequence Detail 3293 Not Applicable  
    polypeptide ENSMUSP00000044554 Ensembl | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      cDNA 155
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145587
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 37
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:344095 Wang Z, et al., Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland. Cell Death Dis. 2023 Oct 13;14(10):675
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory