Tnpo2 MGI Mouse Gene Detail - MGI:2384849 - transportin 2 (importin 3, karyopherin beta 2b)

Symbol

Tnpo2
Name

transportin 2 (importin 3, karyopherin beta 2b)
Synonyms

1110034O24Rik, Kpnb2b, MGC:6380, TRN2

Feature Type

protein coding gene
IDs

MGI:2384849
NCBI Gene: 212999
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:85763544-85784212 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.51 cM
Mapping Data

2 experiments

SNPs within 2kb

433 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384849	protein coding gene	Chr8:85763502-85784214 (+)
129S1/SvImJ	ENSMUSG00200024392	protein coding gene	Chr8:80128539-80149161 (+)
A/J	ENSMUSG00195014951	protein coding gene	Chr8:80486563-80507211 (+)
AKR/J	ENSMUSG00220022795	protein coding gene	Chr8:80528140-80548769 (+)
BALB/cJ	ENSMUSG00180019920	protein coding gene	Chr8:80327256-80347886 (+)
C3H/HeJ	ENSMUSG00175010898	protein coding gene	Chr8:80422247-80442890 (+)
C57BL/6NJ	ENSMUSG00215010349	protein coding gene	Chr8:80059871-80080539 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031326	protein coding gene	Chr8:76387219-76408402 (+)
CAST/EiJ	ENSTCUG00005036187	protein coding gene	Chr8:79936649-79957302 (+)
CBA/J	ENSMUSG00210030589	protein coding gene	Chr8:80409360-80430008 (+)
DBA/2J	ENSMUSG00185037236	protein coding gene	Chr8:86517952-86538597 (+)
FVB/NJ	ENSMUSG00205034785	protein coding gene	Chr8:79465214-79485863 (+)
JF1/MsJ	ENSUMUG00000019850	protein coding gene	Chr8:88826544-88847202 (+)
LP/J	ENSMUSG00230024435	protein coding gene	Chr8:90125520-90146145 (+)
NOD/ShiLtJ	ENSMUSG00190015124	protein coding gene	Chr8:80485665-80506313 (+)
NZO/HlLtJ	ENSMUSG00225040243	protein coding gene	Chr8:93520558-93541226 (+)
PWK/PhJ	ENSLUMG00010028164	protein coding gene	Chr8:80163719-80184393 (+)
SPRET/EiJ	ENSMSPG00010025152	protein coding gene	Chr8:82076291-82094711 (+)
WSB/EiJ	ENSIUOG00005018287	protein coding gene	Chr8:81223472-81244104 (+)

Human Ortholog

TNPO2, transportin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNPO2, transportin 2
Synonyms

IDDHISD, IPO3, KPNB2B, TRN2
Links

HGNC:19998

NCBI Gene ID: 30000

UniProt: O14787
Chr Location

19p13.13; chr19:12699201-12724011 (-) GRCh38

MGI Vertebrate Homology

Tnpo2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNPO2
Gene Tree

Tnpo2

Diseases

1 with human TNPO2 associations

				Human Disease	Mouse Models
				intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies IDs intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies DOID:0081262 KEGG:H02463 OMIM:619556

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

34
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Tnpo2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

668
Tissues

35
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnpo2

ZFIN tnpo2a

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All Sequences

85
RefSeq

28
UniProt

5
CCDS

CCDS22491.1, CCDS90431.1

Ensembl

ENSMUSG00000031691 (Evidence)
NCBI Gene

212999

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031691	Ensembl Gene Model \| MGI Sequence Detail	20669	C57BL/6J	± kb
transcript	ENSMUST00000093360	Ensembl \| MGI Sequence Detail	4863	Not Applicable
polypeptide	ENSMUSP00000091051	Ensembl \| MGI Sequence Detail	897	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016514 transportin-2

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR000357 HEAT repeat

IPR040122 Importin beta family

IPR001494 Importin-beta, N-terminal domain

IPR058584 Importin subunit beta-1/Transportin-1-like, TPR repeats
GlyGen

Q99LG2 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 15

Microarray probesets 5

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MGI:1915911, MGI:2142422, MGI:2142565, MGI:2142636

Summaries

All 77

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 44
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tnpo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78513	Chr8:85763515-85763531 (+)	-21 bp
Tssr78514	Chr8:85763535-85763554 (+)	1 bp
Tssr78515	Chr8:85763555-85763566 (+)	17 bp
Tssr78516	Chr8:85763780-85763839 (+)	266 bp
Tssr78517	Chr8:85763843-85763856 (+)	306 bp
Tssr78518	Chr8:85783851-85783897 (+)	20,330 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24