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Creb3l3 Gene Detail
Summary
  • Symbol
    Creb3l3
  • Name
    cAMP responsive element binding protein 3-like 3
  • Synonyms
    CREB-H, D10Bur1e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384786
    NCBI Gene: 208677
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80920163-80934706 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384786
protein coding gene Chr10:80920158-80934708 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017535
protein coding gene Chr10:81761953-81778219 (-)
A/J MGP_AJ_G0017513
protein coding gene Chr10:78880146-78894561 (-)
AKR/J MGP_AKRJ_G0017474
protein coding gene Chr10:81044010-81061374 (-)
BALB/cJ MGP_BALBcJ_G0017475
protein coding gene Chr10:79094049-79109180 (-)
C3H/HeJ MGP_C3HHeJ_G0017298
protein coding gene Chr10:81126276-81146691 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017929
protein coding gene Chr10:84575888-84591131 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015618
protein coding gene Chr10:75084528-75093404 (-)
CAST/EiJ MGP_CASTEiJ_G0016865
protein coding gene Chr10:81366829-81384163 (-)
CBA/J MGP_CBAJ_G0017270
protein coding gene Chr10:87864745-87881909 (-)
DBA/2J MGP_DBA2J_G0017376
protein coding gene Chr10:78074342-78089042 (-)
FVB/NJ MGP_FVBNJ_G0017370
protein coding gene Chr10:77316731-77331306 (-)
LP/J MGP_LPJ_G0017447
protein coding gene Chr10:82213353-82230009 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017396
protein coding gene Chr10:89736978-89752757 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017970
protein coding gene Chr10:81036100-81051705 (-)
PWK/PhJ MGP_PWKPhJ_G0016646
protein coding gene Chr10:77974992-77991875 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016436
protein coding gene Chr10:79985685-80010006 (-)
WSB/EiJ MGP_WSBEiJ_G0016925
protein coding gene Chr10:81073094-81089216 (-)



Homology
more
  • Human Ortholog
    CREB3L3, cAMP responsive element binding protein 3 like 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB3L3, cAMP responsive element binding protein 3 like 3
  • Synonyms
    CREBH, CREB-H, HYST1481, HYTG2
  • Links
    NCBI Gene ID: 84699
    neXtProt AC: NX_Q68CJ9
    UniProt: Q68CJ9

  • Chr Location
    19p13.3; chr19:4153631-4173054 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and healthy but exhibit reduced expression of acute phase response proteins following treatment with tunicamycin that induces ER stress. Mice homozygous for a different knock-out allele exhibit resistanceto sulpyrine-induced shock.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 208677 NCBI Gene Model | MGI Sequence Detail 14544 C57BL/6J ±  kb
transcript NM_145365 RefSeq | MGI Sequence Detail 2283 ZRU/MplStud  
polypeptide Q91XE9 UniProt | EBI | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005858 cyclic AMP-responsive element-binding protein 3-like protein 3
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR046347 Basic-leucine zipper domain superfamily
Molecular
Reagents
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  • All nucleic 63
    cDNA 60
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1346038
References
more
  • Summaries
    All 71
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:342882 Deng X, et al., CREBH promotes autophagy to ameliorate NASH by regulating Coro1a. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory