Eif4g1 MGI Mouse Gene Detail - MGI:2384784 - eukaryotic translation initiation factor 4, gamma 1

Symbol

Eif4g1
Name

eukaryotic translation initiation factor 4, gamma 1
Synonyms

E030015G23Rik, MGC:37551

Feature Type

protein coding gene
IDs

MGI:2384784
NCBI Gene: 208643
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr16:20491457-20511633 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 12.49 cM
Mapping Data

2 experiments

SNPs within 2kb

488 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384784	protein coding gene	Chr16:20487063-20511634 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022651	protein coding gene	Chr16:18015713-18042822 (+)
A/J	MGP_AJ_G0022613	protein coding gene	Chr16:17143703-17169691 (+)
AKR/J	MGP_AKRJ_G0022588	protein coding gene	Chr16:17790676-17816756 (+)
BALB/cJ	MGP_BALBcJ_G0022617	protein coding gene	Chr16:17301632-17326203 (+)
C3H/HeJ	MGP_C3HHeJ_G0022382	protein coding gene	Chr16:17964723-17990381 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023068	protein coding gene	Chr16:18368851-18394915 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020586	protein coding gene	Chr16:17833232-17853621 (+)
CAST/EiJ	MGP_CASTEiJ_G0021912	protein coding gene	Chr16:17939653-17964474 (+)
CBA/J	MGP_CBAJ_G0022354	protein coding gene	Chr16:19116993-19144427 (+)
DBA/2J	MGP_DBA2J_G0022486	protein coding gene	Chr16:17073300-17095981 (+)
FVB/NJ	MGP_FVBNJ_G0022461	protein coding gene	Chr16:17111393-17137250 (+)
LP/J	MGP_LPJ_G0022553	protein coding gene	Chr16:17741750-17766542 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022481	protein coding gene	Chr16:18790205-18814956 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023079	protein coding gene	Chr16:17769597-17790354 (+)
PWK/PhJ	MGP_PWKPhJ_G0021653	protein coding gene	Chr16:17339937-17366475 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021483	protein coding gene	Chr16:17562010-17588685 (+)
WSB/EiJ	MGP_WSBEiJ_G0021956	protein coding gene	Chr16:17758207-17784262 (+)

Human Ortholog

EIF4G1, eukaryotic translation initiation factor 4 gamma 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF4G1, eukaryotic translation initiation factor 4 gamma 1
Synonyms

EIF4F, EIF4G, EIF-4G1, EIF4GI, P220, PARK18
Links

HGNC:3296

NCBI Gene ID: 1981

UniProt: Q04637
Chr Location

3q27.1; chr3:184314495-184335358 (+) GRCh38

MGI Vertebrate Homology

Eif4g1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EIF4G1
Gene Tree

Eif4g1

Diseases

1 with human EIF4G1 associations

				Human Disease	Mouse Models
				late onset Parkinson's disease IDs late onset Parkinson's disease DOID:0060892 OMIM:168600 ORDO:411602

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Endonuclease-mediated

3
Gene trapped

37
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an amino acid substitution (R1207H) are viable and fertile. Mice lacking the neuronal microexon exhibit social behavior abnormalities, learning and memory deficits, increased inhibitory synaptic conductance, and altered hippocampal synaptic plasticity.

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All GO Annotations

86
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

5
cDNA Data

478
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif4g1

ZFIN eif4g1a

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All Sequences

170
RefSeq

52
UniProt

28
CCDS

CCDS28054.1, CCDS28055.1, CCDS84213.1

Ensembl

ENSMUSG00000045983 (Evidence)
NCBI Gene

208643

			Length	Strain/Species	Flank
genomic	208643	NCBI Gene Model \| MGI Sequence Detail	20177	C57BL/6J	± kb
transcript	NM_001403460	RefSeq \| MGI Sequence Detail	5397	C57BL/6
polypeptide	Q6NZJ6	UniProt \| EBI \| MGI Sequence Detail	1600	Not Applicable

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UniProt

28 Sequences
Protein Ontology

PR:000006998 eukaryotic translation initiation factor 4 gamma 1

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR003891 Initiation factor eIF-4 gamma, MA3

IPR003890 MIF4G-like, type 3

IPR003307 W2 domain
GlyGen

Q6NZJ6 9 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)

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All nucleic 478

cDNA 478

Microarray probesets 7

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MGI:2443563

Summaries

All 60

Developmental Gene Expression 7

Gene Ontology 16

Phenotypes 13
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879

TSS for Eif4g1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137464	Chr16:20491466-20491609 (+)	81 bp
Tssr137465	Chr16:20491637-20491642 (+)	183 bp
Tssr137466	Chr16:20491657-20491668 (+)	206 bp
Tssr137467	Chr16:20491671-20491692 (+)	225 bp
Tssr137468	Chr16:20491846-20491867 (+)	400 bp
Tssr137469	Chr16:20491945-20491995 (+)	513 bp
Tssr137470	Chr16:20492014-20492112 (+)	606 bp
Tssr137471	Chr16:20492284-20492357 (+)	864 bp
Tssr137472	Chr16:20492615-20492637 (+)	1,169 bp
Tssr137473	Chr16:20493004-20493024 (+)	1,557 bp
Tssr137474	Chr16:20494107-20494126 (+)	2,660 bp
Tssr137475	Chr16:20494139-20494180 (+)	2,703 bp
Tssr137476	Chr16:20494476-20494489 (+)	3,026 bp
Tssr137477	Chr16:20496364-20496384 (+)	4,917 bp
Tssr137478	Chr16:20496403-20496422 (+)	4,956 bp
Tssr137479	Chr16:20496960-20497006 (+)	5,526 bp
Tssr137480	Chr16:20497155-20497184 (+)	5,713 bp
Tssr137481	Chr16:20497186-20497201 (+)	5,737 bp
Tssr137482	Chr16:20497387-20497398 (+)	5,936 bp
Tssr137483	Chr16:20498386-20498428 (+)	6,950 bp
Tssr137484	Chr16:20500513-20500534 (+)	9,067 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24