Alg1 MGI Mouse Gene Detail - MGI:2384774 - ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase

Symbol

Alg1
Name

ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
Synonyms

HMAT1, HMT1, MGC:18946

Feature Type

protein coding gene
IDs

MGI:2384774
NCBI Gene: 208211
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:5051485-5062776 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.51 cM
Mapping Data

2 experiments

SNPs within 2kb

112 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384774	protein coding gene	Chr16:5051410-5062776 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022488	protein coding gene	Chr16:1763421-1774712 (+)
A/J	MGP_AJ_G0022450	protein coding gene	Chr16:1573541-1584829 (+)
AKR/J	MGP_AKRJ_G0022427	protein coding gene	Chr16:1762939-1774223 (+)
BALB/cJ	MGP_BALBcJ_G0022455	protein coding gene	Chr16:1720860-1732145 (+)
C3H/HeJ	MGP_C3HHeJ_G0022222	protein coding gene	Chr16:1792736-1804569 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022904	protein coding gene	Chr16:1850816-1862109 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020425	protein coding gene	Chr16:1511783-1522891 (+)
CAST/EiJ	MGP_CASTEiJ_G0021748	protein coding gene	Chr16:1798820-1811529 (+)
CBA/J	MGP_CBAJ_G0022191	protein coding gene	Chr16:1955234-1966515 (+)
DBA/2J	MGP_DBA2J_G0022322	protein coding gene	Chr16:1664058-1675339 (+)
FVB/NJ	MGP_FVBNJ_G0022297	protein coding gene	Chr16:1665373-1676852 (+)
LP/J	MGP_LPJ_G0022390	protein coding gene	Chr16:1756737-1768570 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022319	protein coding gene	Chr16:1797108-1808307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022916	protein coding gene	Chr16:1735266-1746547 (+)
PWK/PhJ	MGP_PWKPhJ_G0021488	protein coding gene	Chr16:1756126-1767424 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021319	protein coding gene	Chr16:1831143-1842361 (+)
WSB/EiJ	MGP_WSBEiJ_G0021797	protein coding gene	Chr16:1768499-1779795 (+)

Human Ortholog

ALG1, ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALG1, ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
Synonyms

CDG1K, hMat-1, HMAT1, HMT1, HMT-1, Mat-1, MT-1
Links

HGNC:18294

NCBI Gene ID: 56052

neXtProt AC: NX_Q9BT22

UniProt: Q9BT22
Chr Location

16p13.3; chr16:5033702-5087379 (+) GRCh38

Human Ortholog

ALG1L1P, ALG1 like 1, pseudogene
Synonyms

ALG1L, ALG1L1
Links

HGNC:33721

NCBI Gene ID: 200810
Chr Location

3q21.2; chr3:125929272-125990537 (-) GRCh38

Human Ortholog

ALG1L2, ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2
Links

HGNC:37258

NCBI Gene ID: 644974

neXtProt AC: NX_C9J202

UniProt: C9J202
Chr Location

3q22.1; chr3:130081831-130113227 (+) GRCh38

MGI Vertebrate Homology

Alg1 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALG1, ALG1L1P, ALG1L2
Gene Tree

Alg1

Diseases

1 with human ALG1 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation Ik IDs congenital disorder of glycosylation Ik DOID:0080563 OMIM:608540 ORDO:79327

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

3
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alg1

ZFIN alg1

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All Sequences

44
RefSeq

8
UniProt

1
CCDS

CCDS49753.1

Ensembl

ENSMUSG00000039427 (Evidence)
NCBI Gene

208211

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039427	Ensembl Gene Model \| MGI Sequence Detail	11292	C57BL/6J	± kb
transcript	ENSMUST00000100196	Ensembl \| MGI Sequence Detail	1755	Not Applicable
polypeptide	ENSMUSP00000097770	Ensembl \| MGI Sequence Detail	482	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003937 chitobiosyldiphosphodolichol beta-mannosyltransferase

(term hierarchy)
EC

2.4.1.142
InterPro Domains

IPR026051 Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like

IPR001296 Glycosyl transferase, family 1

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All nucleic 3

cDNA 3

Microarray probesets 2

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 6
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Alg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136907	Chr16:5051479-5051517 (+)	13 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23