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Tti2 Gene Detail
Summary
  • Symbol
    Tti2
  • Name
    TELO2 interacting protein 2
  • Synonyms
    BC019943, MGC:28346
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384576
    NCBI Gene: 234138
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:31640344-31654731 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 18.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384576
 protein coding gene Chr8:31640343-31654731 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033514
 protein coding gene Chr8:29539480-29553130 (+)
A/J MGP_AJ_G0033494
 protein coding gene Chr8:28376839-28391450 (+)
AKR/J MGP_AKRJ_G0033418
 protein coding gene Chr8:29310190-29325055 (+)
BALB/cJ MGP_BALBcJ_G0033490
 protein coding gene Chr8:28525812-28539480 (+)
C3H/HeJ MGP_C3HHeJ_G0033204
 protein coding gene Chr8:29604492-29618461 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034006
 protein coding gene Chr8:30609556-30637284 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030956
 protein coding gene Chr8:25266771-25280133 (+)
CAST/EiJ MGP_CASTEiJ_G0032529
 protein coding gene Chr8:28986272-29000288 (+)
CBA/J MGP_CBAJ_G0033180
 protein coding gene Chr8:31853341-31869144 (+)
DBA/2J MGP_DBA2J_G0033333
 protein coding gene Chr8:28375040-28388713 (+)
FVB/NJ MGP_FVBNJ_G0033278
 protein coding gene Chr8:28094807-28108373 (+)
LP/J MGP_LPJ_G0033423
 protein coding gene Chr8:29482766-29498198 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033320
 protein coding gene Chr8:31434587-31449510 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034025
 protein coding gene Chr8:29321967-29336159 (+)
PWK/PhJ MGP_PWKPhJ_G0032241
 protein coding gene Chr8:27889348-27904405 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032074
 protein coding gene Chr8:28661137-28675028 (+)
WSB/EiJ MGP_WSBEiJ_G0032645
 protein coding gene Chr8:29489906-29503487 (+)



Homology
more
  • Human Ortholog
    TTI2, TELO2 interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTI2, TELO2 interacting protein 2
  • Synonyms
    C8orf41, MRT39
  • Links
    NCBI Gene ID: 80185
    neXtProt AC: NX_Q6NXR4
    UniProt: Q6NXR4

  • Chr Location
    8p12; chr8:33473386-33513185 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TTI2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 234138 NCBI Gene Model | MGI Sequence Detail 14388 C57BL/6J ±  kb
transcript NR_103719 RefSeq | MGI Sequence Detail 5059 C57BL/6  
polypeptide Q8BGV4 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 6
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:212482 Rao F, et al., Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 2014 Apr 10;54(1):119-32
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory