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Cbr4 Gene Detail
Summary
  • Symbol
    Cbr4
  • Name
    carbonyl reductase 4
  • Synonyms
    A730083J17Rik, MGC:6971
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384567
    NCBI Gene: 234309
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:61940768-61956534 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 31.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384567
protein coding gene Chr8:61940768-61959728 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033635
protein coding gene Chr8:61408588-61428252 (+)
A/J MGP_AJ_G0033617
protein coding gene Chr8:58792734-58808441 (+)
AKR/J MGP_AKRJ_G0033542
protein coding gene Chr8:60483993-60499769 (+)
BALB/cJ MGP_BALBcJ_G0033613
protein coding gene Chr8:59043796-59059610 (+)
C3H/HeJ MGP_C3HHeJ_G0033323
protein coding gene Chr8:61151154-61167612 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034130
protein coding gene Chr8:63744906-63761267 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031078
protein coding gene Chr8:54037164-54053409 (+)
CAST/EiJ MGP_CASTEiJ_G0032648
protein coding gene Chr8:60568636-60584433 (+)
CBA/J MGP_CBAJ_G0033301
protein coding gene Chr8:66051437-66073946 (+)
DBA/2J MGP_DBA2J_G0033455
protein coding gene Chr8:58545963-58561776 (+)
FVB/NJ MGP_FVBNJ_G0033396
protein coding gene Chr8:57848413-57864133 (+)
LP/J MGP_LPJ_G0033543
protein coding gene Chr8:61379952-61399081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033440
protein coding gene Chr8:68158277-68175041 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034148
protein coding gene Chr8:60739029-60756077 (+)
PWK/PhJ MGP_PWKPhJ_G0032357
protein coding gene Chr8:57851995-57868000 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032193
protein coding gene Chr8:59705400-59721526 (+)
WSB/EiJ MGP_WSBEiJ_G0032765
protein coding gene Chr8:61067615-61083587 (+)



Homology
more
  • Human Ortholog
    CBR4, carbonyl reductase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBR4, carbonyl reductase 4
  • Synonyms
    SDR45C1
  • Links
    NCBI Gene ID: 84869
    neXtProt AC: NX_Q8N4T8
    UniProt: Q8N4T8

  • Chr Location
    4q32.3; chr4:168863770-169010275 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234309 NCBI Gene Model | MGI Sequence Detail 15767 C57BL/6J ±  kb
    transcript NM_145595 RefSeq | MGI Sequence Detail 1115 C57BL/6  
    polypeptide Q91VT4 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443029
    References
    more
    • Summaries
      All 34
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory