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Pdk3 Gene Detail
Summary
  • Symbol
    Pdk3
  • Name
    pyruvate dehydrogenase kinase, isoenzyme 3
  • Synonyms
    2610001M10Rik, MGC:6383
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384308
    NCBI Gene: 236900
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:92808213-92875807 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384308
 protein coding gene ChrX:92798923-92875807 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035905
 protein coding gene ChrX:90130704-90202924 (-)
A/J MGP_AJ_G0035891
 protein coding gene ChrX:90233176-90304404 (-)
AKR/J MGP_AKRJ_G0035808
 protein coding gene ChrX:92605561-92672662 (-)
BALB/cJ MGP_BALBcJ_G0035875
 protein coding gene ChrX:88927728-88994860 (-)
C3H/HeJ MGP_C3HHeJ_G0035584
 protein coding gene ChrX:90496569-90568788 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036404
 protein coding gene ChrX:92884217-92959713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033231
 protein coding gene ChrX:88408188-88475768 (-)
CAST/EiJ MGP_CASTEiJ_G0034869
 protein coding gene ChrX:75165045-75231211 (-)
CBA/J MGP_CBAJ_G0035558
 protein coding gene ChrX:95576133-95648093 (-)
DBA/2J MGP_DBA2J_G0035714
 protein coding gene ChrX:89483048-89550103 (-)
FVB/NJ MGP_FVBNJ_G0035653
 protein coding gene ChrX:88876754-88944890 (-)
LP/J MGP_LPJ_G0035802
 protein coding gene ChrX:90919835-90990155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035687
 protein coding gene ChrX:99865227-99937620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036431
 protein coding gene ChrX:89849207-89921427 (-)
PWK/PhJ MGP_PWKPhJ_G0034568
 protein coding gene ChrX:72962216-73028747 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034398
 protein coding gene ChrX:76024391-76091180 (-)
WSB/EiJ MGP_WSBEiJ_G0035010
 protein coding gene ChrX:88652161-88722259 (-)



Homology
more
  • Human Ortholog
    PDK3, pyruvate dehydrogenase kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDK3, pyruvate dehydrogenase kinase 3
  • Synonyms
    CMTX6, GS1-358P8.4
  • Links
    NCBI Gene ID: 5165
    neXtProt AC: NX_Q15120
    UniProt: Q15120

  • Chr Location
    Xp22.11; chrX:24465244-24550466 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDK3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from multigenic genotypes
    7 phenotype references
Mice lacking all 4 Pdk family members exhibit disrupted energy metabolic balance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    103
  • cDNA Data
    14
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035232 Ensembl Gene Model | MGI Sequence Detail 67595 C57BL/6J ±  kb
transcript ENSMUST00000045748 Ensembl | MGI Sequence Detail 2115 Not Applicable  
polypeptide ENSMUSP00000036604 Ensembl | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012506 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
    (term hierarchy)
  • EC
    2.7.11.-, 2.7.11.2
  • InterPro Domains
    IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
    IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    IPR005467 Histidine kinase domain
    IPR003594 Histidine kinase/HSP90-like ATPase
    IPR036890 Histidine kinase/HSP90-like ATPase superfamily
    IPR039028 PDK/BCKDK protein kinase
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914874, MGI:2147840
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:303714 Heinemann-Yerushalmi L, et al., BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development. Dev Cell. 2021 Mar 23;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory