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Mettl22 Gene Detail
Summary
  • Symbol
    Mettl22
  • Name
    methyltransferase 22, Kin17 lysine
  • Synonyms
    MGC:38788
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384301
    NCBI Gene: 239706
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:8288623-8308069 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 3.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    588 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384301
protein coding gene Chr16:8288623-8308548 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022492
protein coding gene Chr16:5121655-5143785 (+)
A/J MGP_AJ_G0022454
protein coding gene Chr16:4814296-4837136 (+)
AKR/J MGP_AKRJ_G0022431
protein coding gene Chr16:5084999-5104009 (+)
BALB/cJ MGP_BALBcJ_G0022459
protein coding gene Chr16:4990704-5010151 (+)
C3H/HeJ MGP_C3HHeJ_G0022226
protein coding gene Chr16:5130893-5151252 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022908
protein coding gene Chr16:5257889-5278199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020429
protein coding gene Chr16:5031812-5051966 (+)
CAST/EiJ MGP_CASTEiJ_G0021752
protein coding gene Chr16:5154653-5173697 (+)
CBA/J MGP_CBAJ_G0022195
protein coding gene Chr16:5468136-5496204 (+)
DBA/2J MGP_DBA2J_G0022326
protein coding gene Chr16:4873042-4893909 (+)
FVB/NJ MGP_FVBNJ_G0022301
protein coding gene Chr16:4854526-4874533 (+)
LP/J MGP_LPJ_G0022394
protein coding gene Chr16:5101733-5122957 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022323
protein coding gene Chr16:5262677-5295289 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022920
protein coding gene Chr16:5038978-5059144 (+)
PWK/PhJ MGP_PWKPhJ_G0021492
protein coding gene Chr16:5041960-5060896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021323
protein coding gene Chr16:5097974-5116287 (+)
WSB/EiJ MGP_WSBEiJ_G0021801
protein coding gene Chr16:5084547-5103787 (+)



Homology
more
  • Human Ortholog
    METTL22, methyltransferase 22, Kin17 lysine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL22, methyltransferase 22, Kin17 lysine
  • Synonyms
    C16orf68
  • Links
    NCBI Gene ID: 79091
    neXtProt AC: NX_Q9BUU2
    UniProt: Q9BUU2

  • Chr Location
    16p13.2; chr16:8621683-8667274 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239706 NCBI Gene Model | MGI Sequence Detail 19447 C57BL/6J ±  kb
    transcript NM_001417200 RefSeq | MGI Sequence Detail 2624 C57BL/6  
    polypeptide Q8R1C6 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 5
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory