About   Help   FAQ
Uts2r Gene Detail
Summary
  • Symbol
    Uts2r
  • Name
    urotensin 2 receptor
  • Synonyms
    Gpr14, urotensin II receptor, UTR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183450
    NCBI Gene: 217369
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr11:121051097-121052799 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 85.02 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183450
protein coding gene Chr11:121051097-121052799 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019540
protein coding gene Chr11:125694357-125696059 (+)
A/J MGP_AJ_G0019507
protein coding gene Chr11:120084497-120086199 (+)
AKR/J MGP_AKRJ_G0019477
protein coding gene Chr11:123719564-123721266 (+)
BALB/cJ MGP_BALBcJ_G0019482
protein coding gene Chr11:120450060-120451762 (+)
C3H/HeJ MGP_C3HHeJ_G0019288
protein coding gene Chr11:124043061-124044763 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019931
protein coding gene Chr11:129511591-129513293 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017556
protein coding gene Chr11:117063096-117064804 (+)
CAST/EiJ MGP_CASTEiJ_G0018842
protein coding gene Chr11:125543008-125544710 (+)
CBA/J MGP_CBAJ_G0019259
protein coding gene Chr11:134544855-134546557 (+)
DBA/2J MGP_DBA2J_G0019372
protein coding gene Chr11:119449153-119450855 (+)
FVB/NJ MGP_FVBNJ_G0019363
protein coding gene Chr11:119166076-119167778 (+)
LP/J MGP_LPJ_G0019443
protein coding gene Chr11:125974668-125976370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019396
protein coding gene Chr11:133357919-133359621 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019970
protein coding gene Chr11:124394971-124396673 (+)
PWK/PhJ MGP_PWKPhJ_G0018609
protein coding gene Chr11:120894026-120895728 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018400
protein coding gene Chr11:124151656-124153358 (+)
WSB/EiJ MGP_WSBEiJ_G0018895
protein coding gene Chr11:124371092-124372794 (+)



Homology
more
  • Human Ortholog
    UTS2R, urotensin 2 receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UTS2R, urotensin 2 receptor
  • Synonyms
    GPR14, UR-2-R, UTR, UTR2
  • Links
    NCBI Gene ID: 2837
    neXtProt AC: NX_Q9UKP6
    UniProt: Q9UKP6

  • Chr Location
    17q25.3; chr17:82371765-82377458 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a selective loss of urotensin-II contractile activity in isolated aortae.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217369 NCBI Gene Model | MGI Sequence Detail 1703 C57BL/6J ±  kb
    transcript NM_145440 RefSeq | MGI Sequence Detail 1703 BALB/c  
    polypeptide Q8VIH9 UniProt | EBI | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:103118 Behm DJ, et al., Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice. Br J Pharmacol. 2003 May;139(2):464-72
    • Latest
      J:334999 Yin L, et al., Urotensin receptor acts as a novel target for ameliorating fasting-induced skeletal muscle atrophy. Pharmacol Res. 2022 Nov;185:106468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory