Nadk MGI Mouse Gene Detail - MGI:2183149

Symbol

Nadk
Name

NAD kinase
Synonyms

4432404C02Rik, MGC:7589

Feature Type

protein coding gene
IDs

MGI:2183149
NCBI Gene: 192185
Alliance

genome feature page
Transcription Start Sites

15 TSS

Sequence Map

Chr4:155646838-155675458 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.44 cM
Mapping Data

2 experiments

SNPs within 2kb

936 from dbSNP Build 142
Strain Annotations

31

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2183149	protein coding gene	Chr4:155646835-155675458 (+)
129S1/SvImJ	ENSMUSG00200019132	protein coding gene	Chr4:146721883-146730389 (+)
129S1/SvImJ	ENSMUSGG00200054934	protein coding gene	Chr4:146716378-146718771 (+)
A/J	ENSMUSGG00195054977	protein coding gene	Chr4:148382436-148384829 (+)
A/J	ENSMUSG00195017665	protein coding gene	Chr4:148387941-148396447 (+)
AKR/J	ENSMUSGG00220054633	protein coding gene	Chr4:147957862-147960255 (+)
AKR/J	ENSMUSG00220026466	protein coding gene	Chr4:147963367-147971873 (+)
BALB/cJ	ENSMUSG00180002281	protein coding gene	Chr4:146042528-146051034 (+)
BALB/cJ	ENSMUSGG00180055381	protein coding gene	Chr4:146037023-146039416 (+)
C3H/HeJ	ENSMUSG00175018434	protein coding gene	Chr4:149343154-149351660 (+)
C3H/HeJ	ENSMUSGG00175054721	protein coding gene	Chr4:149337649-149340042 (+)
C57BL/6NJ	ENSMUSGG00215055715	protein coding gene	Chr4:148184173-148186566 (+)
C57BL/6NJ	ENSMUSG00215009393	protein coding gene	Chr4:148189675-148198181 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026892	protein coding gene	Chr4:145470927-145500361 (+)
CAST/EiJ	ENSTCUG00005031047	protein coding gene	Chr4:152055576-152064075 (+)
CBA/J	ENSMUSGG00210054721	protein coding gene	Chr4:147996000-147998393 (+)
CBA/J	ENSMUSG00210004088	protein coding gene	Chr4:148001505-148010011 (+)
DBA/2J	ENSMUSGG00185057907	protein coding gene	Chr4:151553573-151555966 (+)
DBA/2J	ENSMUSG00185015958	protein coding gene	Chr4:151559078-151567584 (+)
FVB/NJ	ENSMUSGG00205054469	protein coding gene	Chr4:146449128-146451520 (+)
FVB/NJ	ENSMUSG00205015625	protein coding gene	Chr4:146454628-146463134 (+)
JF1/MsJ	ENSUMUG00000000145	protein coding gene	Chr4:154594630-154603069 (+)
LP/J	ENSMUSG00230020851	protein coding gene	Chr4:158284556-158293062 (+)
LP/J	ENSMUSGG00230055558	protein coding gene	Chr4:158279054-158281447 (+)
NOD/ShiLtJ	ENSMUSGG00190055016	protein coding gene	Chr4:147652929-147655321 (+)
NOD/ShiLtJ	ENSMUSG00190003785	protein coding gene	Chr4:147658429-147666935 (+)
NZO/HlLtJ	ENSMUSG00225024359	protein coding gene	Chr4:162281682-162290188 (+)
NZO/HlLtJ	ENSMUSGG00225055275	protein coding gene	Chr4:162276177-162278570 (+)
PWK/PhJ	ENSLUMG00010023718	protein coding gene	Chr4:146848142-146856589 (+)
SPRET/EiJ	ENSMSPG00010019162	protein coding gene	Chr4:148786948-148801251 (+)
WSB/EiJ	ENSIUOG00005005868	protein coding gene	Chr4:145876147-145884653 (+)

Human Ortholog

NADK, NAD kinase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NADK, NAD kinase
Synonyms

dJ283E3.1, NADK1
Links

HGNC:29831

NCBI Gene ID: 65220

UniProt: O95544
Chr Location

1p36.33; chr1:1751232-1780544 (-) GRCh38

MGI Vertebrate Homology

Nadk stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NADK
Gene Tree

Nadk

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

6
Gene trapped

21
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

691
Tissues

94
cDNA Data

251
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nadk

ZFIN nadka, nadkb

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All Sequences

103
RefSeq

12
UniProt

8
CCDS

CCDS19031.1

Ensembl

ENSMUSG00000029063 (Evidence)
NCBI Gene

192185

			Length	Strain/Species	Flank
genomic	192185	NCBI Gene Model \| MGI Sequence Detail	28621	C57BL/6J	± kb
transcript	NM_001159637	RefSeq \| MGI Sequence Detail	3053	C57BL/6
polypeptide	P58058	UniProt \| EBI \| MGI Sequence Detail	439	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000010955 NAD kinase

(term hierarchy)
EC

2.7.1.23
InterPro Domains

IPR017437 ATP-NAD kinase, PpnK-type, C-terminal

IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal

IPR002504 NAD kinase

IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily

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All nucleic 252

cDNA 252

Microarray probesets 4

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MGI:1918027

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:373592 Cunha E Rocha K, et al., Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis. Mol Metab. 2025 Nov;101:102246

TSS for Nadk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40667	Chr4:155646805-155646870 (+)	0 bp
Tssr40668	Chr4:155646871-155646882 (+)	39 bp
Tssr1399	Chr4:155647721-155647731 (+)	888 bp
Tssr40669	Chr4:155647764-155647778 (+)	933 bp
Tssr40670	Chr4:155648189-155648200 (+)	1,357 bp
Tssr40671	Chr4:155648255-155648322 (+)	1,451 bp
Tssr40672	Chr4:155661588-155661621 (+)	14,767 bp
Tssr40673	Chr4:155661912-155661923 (+)	15,080 bp
Tssr40674	Chr4:155666933-155666946 (+)	20,102 bp
Tssr40675	Chr4:155666978-155667004 (+)	20,153 bp
Tssr40676	Chr4:155667192-155667201 (+)	20,359 bp
Tssr40677	Chr4:155667218-155667229 (+)	20,386 bp
Tssr40678	Chr4:155671807-155671821 (+)	24,976 bp
Tssr40679	Chr4:155672365-155672377 (+)	25,533 bp
Tssr40680	Chr4:155674192-155674208 (+)	27,362 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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