Rxfp4 MGI Mouse Gene Detail - MGI:2182926 - relaxin family peptide receptor 4

Symbol

Rxfp4
Name

relaxin family peptide receptor 4
Synonyms

Gpr100, Rln3r2

Feature Type

protein coding gene
IDs

MGI:2182926
NCBI Gene: 242093
Alliance

gene page

Sequence Map

Chr3:88559205-88560449 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.92 cM
Mapping Data

1 experiment

SNPs within 2kb

50 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182926	protein coding gene	Chr3:88559081-88560489 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027405	protein coding gene	Chr3:88831079-88832323 (-)
A/J	MGP_AJ_G0027369	protein coding gene	Chr3:85830710-85831954 (-)
AKR/J	MGP_AKRJ_G0027333	protein coding gene	Chr3:87948525-87949769 (-)
BALB/cJ	MGP_BALBcJ_G0027378	protein coding gene	Chr3:85915337-85916581 (-)
C3H/HeJ	MGP_C3HHeJ_G0027120	protein coding gene	Chr3:88207243-88208487 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027824	protein coding gene	Chr3:92133102-92134346 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025176	protein coding gene	Chr3:81436229-81437631 (-)
CAST/EiJ	MGP_CASTEiJ_G0026566	protein coding gene	Chr3:88443969-88445213 (-)
CBA/J	MGP_CBAJ_G0027094	protein coding gene	Chr3:95299378-95300622 (-)
DBA/2J	MGP_DBA2J_G0027232	protein coding gene	Chr3:85313126-85314370 (-)
FVB/NJ	MGP_FVBNJ_G0027200	protein coding gene	Chr3:83583863-83585107 (-)
LP/J	MGP_LPJ_G0027341	protein coding gene	Chr3:89843781-89845025 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027220	protein coding gene	Chr3:101506067-101507311 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027883	protein coding gene	Chr3:87695183-87696427 (-)
PWK/PhJ	MGP_PWKPhJ_G0026300	protein coding gene	Chr3:85096298-85097543 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026119	protein coding gene	Chr3:86881079-86882323 (-)
WSB/EiJ	MGP_WSBEiJ_G0026648	protein coding gene	Chr3:88050440-88051684 (-)

Human Ortholog

RXFP4, relaxin family peptide/INSL5 receptor 4

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RXFP4, relaxin family peptide/INSL5 receptor 4
Synonyms

GPCR142, GPR100, RLN3R2, RXFPR4
Links

HGNC:14666

NCBI Gene ID: 339403

neXtProt AC: NX_Q8TDU9

UniProt: Q8TDU9
Chr Location

1q22; chr1:155941638-155943087 (+) GRCh38

MGI Vertebrate Homology

Rxfp4 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: RXFP4
Gene Tree

Rxfp4

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References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Rxfp4
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced refeeding responses after fasting, altered food preference, and reduced fat content.

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All GO Annotations

12
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

10
cDNA Data

5
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

4
CCDS

CCDS17482.1

Ensembl

ENSMUSG00000049741 (Evidence)
NCBI Gene

242093

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049741	Ensembl Gene Model \| MGI Sequence Detail	1245	C57BL/6J	± kb
transcript	ENSMUST00000063119	Ensembl \| MGI Sequence Detail	1245	Not Applicable
polypeptide	ENSMUSP00000058732	Ensembl \| MGI Sequence Detail	414	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001553 relaxin-3 receptor 2

(term hierarchy)
InterPro Domains

IPR000248 Angiotensin II receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 5

cDNA 5

Microarray probesets 1

Summaries

All 27

Developmental Gene Expression 1

Diseases 1

Gene Ontology 3

Phenotypes 9
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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