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Med17 Gene Detail
Summary
  • Symbol
    Med17
  • Name
    mediator complex subunit 17
  • Synonyms
    C330002H14Rik, Crsp6, Trap80
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182585
    NCBI Gene: 234959
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:15171647-15191227 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 4.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    649 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182585
 protein coding gene Chr9:15171647-15194576 (-)
129S1/SvImJ ENSMUSGG00200054550
 protein coding gene Chr9:12075161-12083606 (-)
129S1/SvImJ ENSMUSG00200044999
 protein coding gene Chr9:12084882-12093057 (-)
A/J ENSMUSG00195036338
 protein coding gene Chr9:11970496-11978673 (-)
A/J ENSMUSGG00195055073
 protein coding gene Chr9:11960775-11969220 (-)
AKR/J ENSMUSG00220029326
 protein coding gene Chr9:11947932-11956108 (-)
AKR/J ENSMUSGG00220054488
 protein coding gene Chr9:11938210-11946656 (-)
BALB/cJ ENSMUSG00180041143
 protein coding gene Chr9:12094500-12102677 (-)
BALB/cJ ENSMUSGG00180055583
 protein coding gene Chr9:12084778-12093224 (-)
C3H/HeJ ENSMUSG00175041024
 protein coding gene Chr9:12041374-12049550 (-)
C3H/HeJ ENSMUSGG00175054674
 protein coding gene Chr9:12031653-12040098 (-)
C57BL/6NJ ENSMUSG00215036243
 protein coding gene Chr9:12035984-12044159 (-)
C57BL/6NJ ENSMUSGG00215055387
 protein coding gene Chr9:12026263-12034708 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031794
 protein coding gene Chr9:11444713-11463936 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210033121
 protein coding gene Chr9:12072555-12080731 (-)
CBA/J ENSMUSGG00210054681
 protein coding gene Chr9:12062834-12071279 (-)
DBA/2J ENSMUSG00185025848
 protein coding gene Chr9:12161074-12169249 (-)
DBA/2J ENSMUSGG00185057515
 protein coding gene Chr9:12151353-12159798 (-)
FVB/NJ ENSMUSGG00205054185
 protein coding gene Chr9:12135386-12143831 (-)
FVB/NJ ENSMUSG00205019817
 protein coding gene Chr9:12145107-12153282 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230043493
 protein coding gene Chr9:12582946-12591121 (-)
LP/J ENSMUSGG00230055454
 protein coding gene Chr9:12573225-12581670 (-)
NOD/ShiLtJ ENSMUSG00190023569
 protein coding gene Chr9:12071549-12079724 (-)
NOD/ShiLtJ ENSMUSGG00190054681
 protein coding gene Chr9:12061827-12070273 (-)
NZO/HlLtJ ENSMUSG00225049453
 protein coding gene Chr9:12480518-12488692 (-)
NZO/HlLtJ ENSMUSGG00225055627
 protein coding gene Chr9:12470797-12479242 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MED17, mediator complex subunit 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED17, mediator complex subunit 17
  • Synonyms
    CRSP6, CRSP77, DRIP80, SRB4, TRAP80
  • Links
    NCBI Gene ID: 9440
    UniProt: Q9NVC6

  • Chr Location
    11q21; chr11:93784227-93814963 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MED17 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to reduced body weight, breathing difficulties and thymus hypoplasia. Mice die between birth and age eight weeks as a result of abdominal and pulmonary haemorrhage and heart failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    18
  • cDNA Data
    83
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031935 Ensembl Gene Model | MGI Sequence Detail 19581 C57BL/6J ±  kb
transcript ENSMUST00000034411 Ensembl | MGI Sequence Detail 3964 Not Applicable  
polypeptide ENSMUSP00000034411 Ensembl | MGI Sequence Detail 649 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    cDNA 83
    Primer pair 2
    Antibodies 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2443890
References
more
  • Summaries
    All 52
    Developmental Gene Expression 5
    Gene Ontology 13
    Phenotypes 9
  • Earliest
    J:320035 Mittler G, et al., Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep. 2001 Sep;2(9):808-13
  • Latest
    J:379748 Zhu S, et al., The essential role of MED27 in stabilizing the mediator complex for cardiac development and function. Life Sci. 2024 Nov 1;356:123020
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory