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Mtnr1b Gene Detail
Summary
  • Symbol
    Mtnr1b
  • Name
    melatonin receptor 1B
  • Synonyms
    Mel1b, Mt2
Location &
Maps
more
  • Sequence Map
    Chr9:15773910-15785852 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 5.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    519 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181726
 protein coding gene Chr9:15735824-15785852 (-)
129S1/SvImJ ENSMUSG00200044069
 protein coding gene Chr9:12638225-12688258 (-)
A/J ENSMUSG00195032861
 protein coding gene Chr9:12523500-12573532 (-)
AKR/J ENSMUSG00220031741
 protein coding gene Chr9:12501248-12551277 (-)
BALB/cJ ENSMUSG00180037918
 protein coding gene Chr9:12647845-12697875 (-)
C3H/HeJ ENSMUSG00175042303
 protein coding gene Chr9:12600051-12650078 (-)
C57BL/6NJ ENSMUSG00215021233
 protein coding gene Chr9:12589321-12639352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031801
 protein coding gene Chr9:12004649-12049184 (-)
CAST/EiJ ENSTCUG00005028082
 protein coding gene Chr9:12646876-12693363 (-)
CBA/J ENSMUSG00210034508
 protein coding gene Chr9:12625858-12675888 (-)
DBA/2J ENSMUSG00185022554
 protein coding gene Chr9:12714393-12764423 (-)
FVB/NJ ENSMUSG00205037460
 protein coding gene Chr9:12696504-12746538 (-)
JF1/MsJ ENSUMUG00000018890
 protein coding gene Chr9:12726231-12779018 (-)
LP/J ENSMUSG00230043167
 protein coding gene Chr9:13136244-13186272 (-)
NOD/ShiLtJ ENSMUSG00190029401
 protein coding gene Chr9:12624863-12674893 (-)
NZO/HlLtJ ENSMUSG00225048384
 protein coding gene Chr9:13032957-13083012 (-)
PWK/PhJ ENSLUMG00010043083
 protein coding gene Chr9:12655963-12712681 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005036298
 protein coding gene Chr9:12302686-12350807 (-)



Homology
more
  • Human Ortholog
    MTNR1B, melatonin receptor 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTNR1B, melatonin receptor 1B
  • Synonyms
    FGQTL2, MEL-1B-R, MT2
  • Links
    NCBI Gene ID: 4544
    UniProt: P49286

  • Chr Location
    11q14.3; chr11:92969651-92985066 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MTNR1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and display no obvious circadian phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    35
  • cDNA Data
    4
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 244701 NCBI Gene Model | MGI Sequence Detail 11943 C57BL/6J ±  kb
transcript NM_145712 RefSeq | MGI Sequence Detail 1244 C57BL/6  
polypeptide Q8CIQ6 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Primer pair 1
    Antibodies 2

    Microarray probesets 1
References
more
  • Summaries
    All 72
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 39
  • Earliest
    J:76848 Weaver DR, et al., Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov;10(11):1478-87
  • Latest
    J:382802 Yang G, et al., Melatonin promotes embryonic development by enhancing tryptophan metabolism and NAD + synthesis. BMC Biol. 2026 Feb 16;24(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory