Ggn MGI Mouse Gene Detail - MGI:2181461

Symbol

Ggn
Name

gametogenetin
Synonyms

GGN1, GGN2, GGN3

Feature Type

protein coding gene
IDs

MGI:2181461
NCBI Gene: 243897
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:28869635-28873363 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM
Mapping Data

1 experiment

SNPs within 2kb

107 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181461	protein coding gene	Chr7:28869635-28873401 (+)
129S1/SvImJ	ENSMUSG00200043250	protein coding gene	Chr7:18669797-18673569 (+)
A/J	ENSMUSG00195043390	protein coding gene	Chr7:21336447-21340205 (+)
AKR/J	ENSMUSG00220048385	protein coding gene	Chr7:23153058-23156824 (-)
BALB/cJ	ENSMUSG00180051261	protein coding gene	Chr7:19395960-19399718 (+)
C3H/HeJ	ENSMUSG00175030866	protein coding gene	Chr7:20435557-20439323 (+)
C57BL/6NJ	ENSMUSG00215054123	protein coding gene	Chr7:18559742-18563508 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029475	protein coding gene	Chr7:28395163-28398853 (+)
CAST/EiJ	ENSTCUG00005048721	protein coding gene	Chr7:20377508-20381280 (+)
CBA/J	ENSMUSG00210052940	protein coding gene	Chr7:19620064-19623830 (+)
DBA/2J	ENSMUSG00185044550	protein coding gene	Chr7:22721305-22725071 (+)
FVB/NJ	ENSMUSG00205049561	protein coding gene	Chr7:19401958-19405716 (+)
JF1/MsJ	ENSUMUG00000050223	protein coding gene	Chr7:27136465-27140238 (+)
LP/J	ENSMUSG00230053110	protein coding gene	Chr7:27891829-27895595 (+)
NOD/ShiLtJ	ENSMUSG00190039898	protein coding gene	Chr7:19055581-19059347 (+)
NZO/HlLtJ	ENSMUSG00225026627	protein coding gene	Chr7:26734981-26738747 (+)
PWK/PhJ	ENSLUMG00010045595	protein coding gene	Chr7:19101439-19105211 (+)
SPRET/EiJ	ENSMSPG00010048075	protein coding gene	Chr7:18448747-18452314 (+)
WSB/EiJ	ENSIUOG00005053457	protein coding gene	Chr7:13326583-13330355 (+)

Human Ortholog

GGN, gametogenetin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GGN, gametogenetin
Links

HGNC:18869

NCBI Gene ID: 199720

UniProt: Q86UU5
Chr Location

19q13.2; chr19:38384267-38388384 (-) GRCh38

MGI Vertebrate Homology

Ggn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GGN
Gene Tree

Ggn

Diseases

1 with human GGN associations

				Human Disease	Mouse Models
				spermatogenic failure 69 IDs spermatogenic failure 69 DOID:0070568 OMIM:619826

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype reference

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice heterozygous for this allele exhibit impaired double-strand break repair in spermatocytes.

less

All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

610
Tissues

10
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

53
RefSeq

11
UniProt

4
CCDS

CCDS21067.1, CCDS52168.1, CCDS90196.1

Ensembl

ENSMUSG00000031493 (Evidence)
NCBI Gene

243897

			Length	Strain/Species	Flank
genomic	243897	NCBI Gene Model \| MGI Sequence Detail	3729	C57BL/6J	± kb
transcript	NM_182694	RefSeq \| MGI Sequence Detail	2653	C57BL/6
polypeptide	Q80WJ1	UniProt \| EBI \| MGI Sequence Detail	673	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000007958 gametogenetin

(term hierarchy)
InterPro Domains

IPR031400 Gametogenetin
GlyGen

Q80WJ1 10 sites

less

All nucleic 15

cDNA 14

Primer pair 1

Antibodies 1

Microarray probesets 3

less

MGI:2142005

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 1
Earliest

J:84438 Lu B, et al., Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. J Biol Chem. 2003 May 2;278(18):16289-96
Latest

J:278492 Guo K, et al., Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice. J Cell Mol Med. 2018 Oct;22(10):4863-4874

TSS for Ggn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65603	Chr7:28869629-28869649 (+)	4 bp
Tssr65604	Chr7:28869665-28869674 (+)	35 bp
Tssr65605	Chr7:28869745-28869752 (+)	114 bp
Tssr65606	Chr7:28869770-28869839 (+)	170 bp
Tssr65607	Chr7:28870276-28870285 (+)	646 bp
Tssr65608	Chr7:28870829-28870852 (+)	1,206 bp
Tssr65609	Chr7:28871764-28871771 (+)	2,133 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24