Oas1f MGI Mouse Gene Detail - MGI:2180855 - 2'-5' oligoadenylate synthetase 1F

Symbol

Oas1f
Name

2'-5' oligoadenylate synthetase 1F

Feature Type

protein coding gene
IDs

MGI:2180855
NCBI Gene: 243262
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:120985432-120996049 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.64 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

510 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180855	protein coding gene	Chr5:120985432-120996049 (+)
129S1/SvImJ	ENSMUSG00200023932	protein coding gene	Chr5:114724682-114735298 (+)
A/J	ENSMUSG00195010714	protein coding gene	Chr5:114245870-114256491 (+)
AKR/J	ENSMUSG00220045096	protein coding gene	Chr5:113746806-113757429 (+)
BALB/cJ	ENSMUSG00180032493	protein coding gene	Chr5:114360469-114371085 (+)
C3H/HeJ	ENSMUSG00175020718	protein coding gene	Chr5:116358510-116369128 (+)
C57BL/6NJ	ENSMUSG00215043200	protein coding gene	Chr5:114392361-114402978 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027674	protein coding gene	Chr5:113867125-113876438 (+)
CAST/EiJ	ENSTCUG00005037475	protein coding gene	Chr5:113560383-113570798 (+)
CBA/J	ENSMUSG00210007322	protein coding gene	Chr5:115109390-115120008 (+)
DBA/2J	ENSMUSG00185052812	protein coding gene	Chr5:118168703-118179320 (+)
FVB/NJ	ENSMUSG00205043300	protein coding gene	Chr5:114022523-114033144 (+)
JF1/MsJ	ENSUMUG00000049142	protein coding gene	Chr5:121011559-121022162 (+)
LP/J	ENSMUSG00230039567	protein coding gene	Chr5:122246880-122257496 (+)
NOD/ShiLtJ	ENSMUSG00190024867	protein coding gene	Chr5:114056594-114067210 (+)
NZO/HlLtJ	ENSMUSG00225014226	protein coding gene	Chr5:129923993-129934622 (+)
PWK/PhJ	ENSLUMG00010029700	protein coding gene	Chr5:112914287-112924827 (+)
SPRET/EiJ	ENSMSPG00010034296	protein coding gene	Chr5:116236619-116247322 (+)
WSB/EiJ	ENSIUOG00005016792	protein coding gene	Chr5:116740967-116751538 (+)

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1
Synonyms

E18/E16, IFI-4, IMD100, OIAS, OIASI
Links

HGNC:8086

NCBI Gene ID: 4938

UniProt: P00973
Chr Location

12q24.13; chr12:112905856-112933219 (+) GRCh38

MGI Vertebrate Homology

Oas1f stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OAS1
Gene Tree

Oas1f

Diseases

1 with human OAS1 associations

				Human Disease	Mouse Models
				immunodeficiency 100 IDs immunodeficiency 100 DOID:0061070 OMIM:618042

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Oas1f
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

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All GO Annotations

34
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

5
CCDS

CCDS19628.1

Ensembl

ENSMUSG00000053765 (Evidence)
NCBI Gene

243262

			Length	Strain/Species	Flank
genomic	243262	NCBI Gene Model \| MGI Sequence Detail	10618	C57BL/6J	± kb
transcript	NM_145153	RefSeq \| MGI Sequence Detail	1480	ZRU/MplStud
polypeptide	NP_660135	RefSeq \| MGI Sequence Detail	364	ZRU/MplStud

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UniProt

5 Sequences
InterPro Domains

IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain

IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal

IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site

IPR043519 Nucleotidyltransferase superfamily

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All nucleic 7

Genomic 1

cDNA 6

Microarray probesets 3

Summaries

All 29

Gene Ontology 3

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7

TSS for Oas1f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48549	Chr5:120985429-120985456 (+)	11 bp
Tssr48550	Chr5:120985476-120985488 (+)	50 bp
Tssr48551	Chr5:120992373-120992375 (+)	6,942 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29