Oas1f MGI Mouse Gene Detail - MGI:2180855 - 2'-5' oligoadenylate synthetase 1F

Symbol

Oas1f
Name

2'-5' oligoadenylate synthetase 1F

Feature Type

protein coding gene
IDs

MGI:2180855
NCBI Gene: 243262
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:120985432-120996049 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.64 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

9 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180855	protein coding gene	Chr5:120985432-120996049 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030016	protein coding gene	Chr5:124268620-124280205 (+)
A/J	MGP_AJ_G0029981	protein coding gene	Chr5:119105519-119117626 (+)
AKR/J	MGP_AKRJ_G0029919	protein coding gene	Chr5:122961416-122972037 (+)
BALB/cJ	MGP_BALBcJ_G0029992	protein coding gene	Chr5:120514935-120525526 (+)
C3H/HeJ	MGP_C3HHeJ_G0029712	protein coding gene	Chr5:123530379-123542285 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030447	protein coding gene	Chr5:128952966-128964086 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027674	protein coding gene	Chr5:113867125-113876438 (+)
CAST/EiJ	MGP_CASTEiJ_G0029120	protein coding gene	Chr5:122649263-122660857 (+)
CBA/J	MGP_CBAJ_G0029680	protein coding gene	Chr5:133985585-133996018 (+)
DBA/2J	MGP_DBA2J_G0029830	protein coding gene	Chr5:119204461-119217881 (+)
FVB/NJ	MGP_FVBNJ_G0029785	protein coding gene	Chr5:118144347-118157095 (+)
LP/J	MGP_LPJ_G0029918	protein coding gene	Chr5:124733062-124749702 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029816	protein coding gene	Chr5:137912670-137933553 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030488	protein coding gene	Chr5:122532338-122544572 (+)
PWK/PhJ	MGP_PWKPhJ_G0028833	protein coding gene	Chr5:117977412-117989067 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028672	protein coding gene	Chr5:120235696-120253017 (+)
WSB/EiJ	MGP_WSBEiJ_G0029195	protein coding gene	Chr5:123138306-123149201 (+)

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1
Synonyms

E18/E16, IFI-4, IMD100, OIAS, OIASI
Links

HGNC:8086

NCBI Gene ID: 4938

neXtProt AC: NX_P00973

UniProt: P00973
Chr Location

12q24.13; chr12:112905856-112933219 (+) GRCh38

MGI Vertebrate Homology

Oas1f stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OAS1
Gene Tree

Oas1f

Diseases

1 with human OAS1 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Oas1f
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

39
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS19628.1

Ensembl

ENSMUSG00000053765 (Evidence)
NCBI Gene

243262

			Length	Strain/Species	Flank
genomic	243262	NCBI Gene Model \| MGI Sequence Detail	10618	C57BL/6J	± kb
transcript	NM_145153	RefSeq \| MGI Sequence Detail	1480	ZRU/MplStud
polypeptide	NP_660135	RefSeq \| MGI Sequence Detail	364	ZRU/MplStud

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UniProt

4 Sequences
InterPro Domains

IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain

IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal

IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site

IPR043519 Nucleotidyltransferase superfamily

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All nucleic 7

Genomic 1

cDNA 6

Microarray probesets 3

Summaries

All 27

Gene Ontology 2

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7

TSS for Oas1f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48549	Chr5:120985429-120985456 (+)	11 bp
Tssr48550	Chr5:120985476-120985488 (+)	50 bp
Tssr48551	Chr5:120992373-120992375 (+)	6,942 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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