About   Help   FAQ
Oasl1 Gene Detail
Summary
  • Symbol
    Oasl1
  • Name
    2'-5' oligoadenylate synthetase-like 1
  • Synonyms
    7530414C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180849
    NCBI Gene: 231655
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115061299-115075974 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180849
 protein coding gene Chr5:115061236-115075974 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029952
 protein coding gene Chr5:117725808-117744960 (+)
A/J MGP_AJ_G0029917
 protein coding gene Chr5:113075103-113089874 (+)
AKR/J MGP_AKRJ_G0029855
 protein coding gene Chr5:116671673-116691805 (+)
BALB/cJ MGP_BALBcJ_G0029928
 protein coding gene Chr5:114469673-114485073 (+)
C3H/HeJ MGP_C3HHeJ_G0029647
 protein coding gene Chr5:117198231-117214006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030382
 protein coding gene Chr5:122283851-122300590 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027609
 protein coding gene Chr5:107868349-107882589 (+)
CAST/EiJ MGP_CASTEiJ_G0029056
 protein coding gene Chr5:116108068-116125322 (+)
CBA/J MGP_CBAJ_G0029615
 protein coding gene Chr5:126943077-126960781 (+)
DBA/2J MGP_DBA2J_G0029765
 protein coding gene Chr5:113155552-113169959 (+)
FVB/NJ MGP_FVBNJ_G0029721
 protein coding gene Chr5:111959458-111975235 (+)
LP/J MGP_LPJ_G0029853
 protein coding gene Chr5:118304900-118322711 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029752
 protein coding gene Chr5:131314938-131330433 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030423
 protein coding gene Chr5:116146701-116165397 (+)
PWK/PhJ MGP_PWKPhJ_G0028769
 protein coding gene Chr5:111797921-111818538 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028607
 protein coding gene Chr5:113699722-113715208 (+)
WSB/EiJ MGP_WSBEiJ_G0029131
 protein coding gene Chr5:116734192-116749721 (+)



Homology
more
  • Human Ortholog
    OASL, 2'-5'-oligoadenylate synthetase like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OASL, 2'-5'-oligoadenylate synthetase like
  • Synonyms
    OASL1, OASLd, p59OASL, p59 OASL, p59-OASL, TRIP14, TRIP-14
  • Links
    NCBI Gene ID: 8638
    neXtProt AC: NX_Q15646
    UniProt: Q15646

  • Chr Location
    12q24.31; chr12:121017761-121039246 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Oasl1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    33 strains or lines available
Mice with a deletion of this gene have increased expression of type I interferon and show increased resistance to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    26
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041827 Ensembl Gene Model | MGI Sequence Detail 14676 C57BL/6J ±  kb
transcript ENSMUST00000031540 Ensembl | MGI Sequence Detail 2125 Not Applicable  
polypeptide ENSMUSP00000031540 Ensembl | MGI Sequence Detail 511 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011577 2'-5'-oligoadenylate synthase-like protein 1
    (term hierarchy)
  • InterPro Domains
    IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site
    IPR043519 Nucleotidyltransferase superfamily
    IPR000626 Ubiquitin-like domain
    IPR029071 Ubiquitin-like domain superfamily
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 4
Other
Accession IDs
less
MGI:2443464
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:333834 Kim TK, et al., 2'-5' oligoadenylate synthetaselike 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability. Nat Commun. 2022 Nov 4;13(1):6647
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory