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Prok1 Gene Detail
Summary
  • Symbol
    Prok1
  • Name
    prokineticin 1
  • Synonyms
    EG-VEGF
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180370
    NCBI Gene: 246691
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107140113-107147023 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180370
 protein coding gene Chr3:107139232-107147023 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027744
 protein coding gene Chr3:108710879-108719014 (-)
A/J MGP_AJ_G0027704
 protein coding gene Chr3:105268693-105275601 (-)
AKR/J MGP_AKRJ_G0027669
 protein coding gene Chr3:107840425-107847333 (-)
BALB/cJ MGP_BALBcJ_G0027716
 protein coding gene Chr3:104965602-104972508 (-)
C3H/HeJ MGP_C3HHeJ_G0027446
 protein coding gene Chr3:108181354-108188262 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028160
 protein coding gene Chr3:112789618-112797972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025498
 protein coding gene Chr3:101430912-101437797 (-)
CAST/EiJ MGP_CASTEiJ_G0026902
 protein coding gene Chr3:107552164-107558359 (-)
CBA/J MGP_CBAJ_G0027421
 protein coding gene Chr3:116601574-116608476 (-)
DBA/2J MGP_DBA2J_G0027563
 protein coding gene Chr3:104470165-104477073 (-)
FVB/NJ MGP_FVBNJ_G0027531
 protein coding gene Chr3:102350015-102356926 (-)
LP/J MGP_LPJ_G0027670
 protein coding gene Chr3:110127595-110134506 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027561
 protein coding gene Chr3:122727012-122733918 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028215
 protein coding gene Chr3:107426991-107434971 (-)
PWK/PhJ MGP_PWKPhJ_G0026628
 protein coding gene Chr3:104195629-104202656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026448
 protein coding gene Chr3:105563995-105571367 (-)
WSB/EiJ MGP_WSBEiJ_G0026982
 protein coding gene Chr3:107953286-107960188 (-)



Homology
more
  • Human Ortholog
    PROK1, prokineticin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROK1, prokineticin 1
  • Synonyms
    EGVEGF, PK1, PRK1
  • Links
    NCBI Gene ID: 84432
    neXtProt AC: NX_P58294
    UniProt: P58294

  • Chr Location
    1p13.3; chr1:110451149-110457358 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Prok1
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    17
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070368 Ensembl Gene Model | MGI Sequence Detail 6911 C57BL/6J ±  kb
transcript ENSMUST00000049852 Ensembl | MGI Sequence Detail 813 Not Applicable  
polypeptide ENSMUSP00000060617 Ensembl | MGI Sequence Detail 105 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 7
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory