Zar1 Gene Detail

Summary

• Symbol
  Zar1
• Name
  zygote arrest 1

• Feature Type
  protein coding gene
• IDs
  MGI:2180337
  NCBI Gene: 317755
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr5:72734457-72738427 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• Per David Webb This Slc10a4> Zar1>duplication appears to be restricted to M. musculus and M. caroli. I couldn't find a similar duplication in other Mus assemblies (eg, M. pahari, M. spicilegus...) or in the assemblies of Peromyscus maniculatus, beaver or human. The gene order in M. musculus and M. caroli is: Nfxl1< loc> Zar1< Slc10a4ps< Cnga1< Nipal1> Txk< Tec< Slain2> Slc10a4> Zar1ps> Fryl< whereas the following gene order is strongly conserved in all other gnathostomes except teleosts: NFXL1< CNGA1< NIPAL1> TXK< TEC< SLAIN2> SLC10A4> ZAR1> FRYL< So, while the protein coding Zar1 gene (GeneID: 317755, MGI:2180337) of M. musculus isn't strictly the ortholog of the ZAR1 gene in other mammals the difference is trivial since it's restricted to a very small set of Mus-related organisms. The Slc10a4 gene of of M. musculus (GeneID: 231290, MGI:3606480) is a true ortholog of the gene in other mammals.

• Genetic Map
  Chromosome 5, 38.44 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  193 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180337	protein coding gene	Chr5:72734149-72738597 (-)
129S1/SvImJ	ENSMUSG00200035327	protein coding gene	Chr5:68391763-68395908 (-)
A/J	ENSMUSG00195031140	protein coding gene	Chr5:67715991-67720136 (-)
AKR/J	ENSMUSG00220003198	protein coding gene	Chr5:67827644-67831789 (-)
BALB/cJ	ENSMUSG00180021238	protein coding gene	Chr5:67472983-67477128 (-)
C3H/HeJ	ENSMUSG00175026284	protein coding gene	Chr5:69522568-69526718 (-)
C57BL/6NJ	ENSMUSG00215004747	protein coding gene	Chr5:68307128-68311273 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027284	protein coding gene	Chr5:65519199-65523363 (-)
CAST/EiJ	ENSTCUG00005029225	protein coding gene	Chr5:67271942-67276143 (-)
CBA/J	ENSMUSG00210023397	protein coding gene	Chr5:68460771-68464921 (-)
DBA/2J	ENSMUSG00185005472	protein coding gene	Chr5:70290395-70294545 (-)
FVB/NJ	ENSMUSG00205025403	protein coding gene	Chr5:67268363-67272509 (-)
JF1/MsJ	ENSUMUG00000004908	protein coding gene	Chr5:74771819-74776002 (-)
LP/J	ENSMUSG00230015907	protein coding gene	Chr5:74966151-74970296 (-)
NOD/ShiLtJ	ENSMUSG00190004004	protein coding gene	Chr5:67389288-67393438 (-)
NZO/HlLtJ	ENSMUSG00225009428	protein coding gene	Chr5:80036336-80040481 (-)
PWK/PhJ	ENSLUMG00010011726	protein coding gene	Chr5:67360578-67364754 (-)
SPRET/EiJ	ENSMSPG00010030838	protein coding gene	Chr5:69334581-69338741 (-)
WSB/EiJ	ENSIUOG00005016714	protein coding gene	Chr5:70252503-70256655 (-)

Homology

• Human Ortholog
  ZAR1, zygote arrest 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ZAR1, zygote arrest 1
  
• Synonyms
  Z3CXXC6
• Links
  HGNC:20436

  NCBI Gene ID: 326340

  UniProt: Q86SH2

  
  
• Chr Location
  4p11; chr4:48490252-48497635 (+)  GRCh38

---

• MGI Vertebrate Homology
  Zar1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ZAR1
• Gene Tree
  Zar1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 2 alleles in 3 genetic backgrounds
  5 phenotypes from multigenic genotypes
  25 phenotype references
  

• All Mutations and Alleles
  11
• Chemically induced (other)
  2
• Endonuclease-mediated
  3
• Radiation induced
  1
• Spontaneous
  1
• Targeted
  4
• Genomic Mutations
  4 involving Zar1
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  15 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Ovarian development and oogenesis are normal in homozygous null females; however, they are infertile due to a failure at the oocyte to embryo transition.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  18
• GO References
  7

Expression

• Assay Results
  666
• Tissues
  26
• cDNA Data
  12
• Literature Summary
  12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase zar1
  ZFIN zar1

Sequences &
Gene Models

• All Sequences
  39
• RefSeq
  4
• UniProt
  2
• CCDS
  CCDS19331.1

• Ensembl
  ENSMUSG00000063935 (Evidence)
• NCBI Gene
  317755

Representative Sequences			Length	Strain/Species
genomic	317755	NCBI Gene Model | MGI Sequence Detail	3971	C57BL/6J
transcript	NM_174877	RefSeq | MGI Sequence Detail	1284	C57BL/6
polypeptide	Q80SU3	UniProt | EBI | MGI Sequence Detail	361	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000017558 zygote arrest protein 1
  (term hierarchy)
• InterPro Domains
  IPR027377 ZAR1/RTP1-5-like, 3CxxC-type zinc finger
  IPR026775 Zygote arrest protein 1

Molecular
Reagents

• All nucleic 13

  cDNA 12

  Primer pair 1

  Antibodies 3

  
  

  Microarray probesets 4

References

• Summaries
  All 55

  Developmental Gene Expression 12

  Gene Ontology 7

  Phenotypes 25
• Earliest
  J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
• Latest
  J:384897 Hu FJ, et al., Heterogeneous nuclear ribonucleoprotein L orchestrates alternative splicing critical for primordial follicle formation. J Adv Res. 2026 Feb 19;