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Defb35 Gene Detail
Summary
  • Symbol
    Defb35
  • Name
    defensin beta 35
Location &
Maps
more
  • Sequence Map
    Chr8:22428368-22430894 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.66 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    156 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179204
 protein coding gene Chr8:22428368-22430894 (+)
129S1/SvImJ ENSMUSG00200028872
 protein coding gene Chr8:17472963-17475486 (+)
A/J ENSMUSG00195041564
 protein coding gene Chr8:18024389-18026912 (+)
AKR/J ENSMUSG00220027571
 protein coding gene Chr8:17644590-17647114 (+)
BALB/cJ ENSMUSG00180021581
 protein coding gene Chr8:17549044-17551567 (+)
C3H/HeJ ENSMUSG00175038570
 protein coding gene Chr8:17615403-17617926 (+)
C57BL/6NJ ENSMUSG00215015503
 protein coding gene Chr8:17484472-17486998 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030871
 protein coding gene Chr8:15309801-15310018 (-)
CAST/EiJ ENSTCUG00005018506
 protein coding gene Chr8:17865994-17868509 (+)
CBA/J ENSMUSG00210039656
 protein coding gene Chr8:17548696-17551219 (+)
DBA/2J ENSMUSG00185033025
 protein coding gene Chr8:23351702-23354225 (+)
FVB/NJ ENSMUSG00205028642
 protein coding gene Chr8:17040904-17043427 (+)
JF1/MsJ ENSUMUG00000014760
 protein coding gene Chr8:25246264-25248774 (+)
LP/J ENSMUSG00230009268
 protein coding gene Chr8:27120881-27123400 (+)
NOD/ShiLtJ ENSMUSG00190034904
 protein coding gene Chr8:17582213-17584736 (+)
NZO/HlLtJ ENSMUSG00225019033
 protein coding gene Chr8:30724650-30727176 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005019611
 protein coding gene Chr8:18275768-18278292 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246084 NCBI Gene Model | MGI Sequence Detail 2527 C57BL/6J ±  kb
transcript NM_139224 RefSeq | MGI Sequence Detail 267 C57BL/6  
polypeptide Q8R2I3 UniProt | EBI | MGI Sequence Detail 63 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 17
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:82526 Morrison GM, et al., Signal Sequence Conservation and Mature Peptide Divergence Within Subgroups of the Murine beta-Defensin Gene Family. Mol Biol Evol. 2003 Mar;20(3):460-70
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory