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Defb15 Gene Detail
Summary
  • Symbol
    Defb15
  • Name
    defensin beta 15
  • Synonyms
    Defb11, mBD-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179202
    NCBI Gene: 246082
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22419815-22422726 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.64 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179202
 protein coding gene Chr8:22419813-22422728 (-)
129S1/SvImJ ENSMUSG00200028865
 protein coding gene Chr8:17464415-17467326 (-)
A/J ENSMUSG00195041551
 protein coding gene Chr8:18015841-18018752 (-)
AKR/J ENSMUSG00220027558
 protein coding gene Chr8:17636035-17638947 (-)
BALB/cJ ENSMUSG00180021561
 protein coding gene Chr8:17540496-17543407 (-)
C3H/HeJ ENSMUSG00175038541
 protein coding gene Chr8:17606855-17609766 (-)
C57BL/6NJ ENSMUSG00215015483
 protein coding gene Chr8:17475919-17478830 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030872
 protein coding gene Chr8:15319394-15322280 (+)
CAST/EiJ ENSTCUG00005018503
 protein coding gene Chr8:17857469-17860383 (-)
CBA/J ENSMUSG00210039634
 protein coding gene Chr8:17540148-17543059 (-)
DBA/2J ENSMUSG00185032994
 protein coding gene Chr8:23343154-23346065 (-)
FVB/NJ ENSMUSG00205028603
 protein coding gene Chr8:17032356-17035267 (-)
JF1/MsJ ENSUMUG00000014723
 protein coding gene Chr8:25237789-25240670 (-)
LP/J ENSMUSG00230009256
 protein coding gene Chr8:27112317-27115228 (-)
NOD/ShiLtJ ENSMUSG00190034876
 protein coding gene Chr8:17573665-17576576 (-)
NZO/HlLtJ ENSMUSG00225019025
 protein coding gene Chr8:30716097-30719008 (-)
PWK/PhJ ENSLUMG00010027028
 protein coding gene Chr8:17597424-17600305 (-)
SPRET/EiJ ENSMSPG00010012976
 protein coding gene Chr8:17841582-17844490 (-)
WSB/EiJ ENSIUOG00005019601
 protein coding gene Chr8:18267213-18270125 (-)



Homology
more
  • Human Ortholog
    DEFB106A, defensin beta 106A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB106A, defensin beta 106A
  • Synonyms
    BD-6, DEFB106, DEFB-6
  • Links
    NCBI Gene ID: 245909
    UniProt: Q8N104

  • Chr Location
    8p23.1
  • Human Ortholog
    DEFB106B, defensin beta 106B
  • Synonyms
    BD-6, DEFB-6
  • Links
    NCBI Gene ID: 503841
    UniProt: Q8N104

  • Chr Location
    8p23.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048500 Ensembl Gene Model | MGI Sequence Detail 2912 C57BL/6J ±  kb
transcript ENSMUST00000062586 Ensembl | MGI Sequence Detail 345 Not Applicable  
polypeptide ENSMUSP00000059763 Ensembl | MGI Sequence Detail 79 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 23
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:75063 Schutte BC, et al., Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory