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Defb7 Gene Detail
Summary
  • Symbol
    Defb7
  • Name
    defensin beta 7
  • Synonyms
    Defb15, mBD7
Location &
Maps
more
  • Sequence Map
    Chr8:19545113-19547791 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179200
 protein coding gene Chr8:19545113-19547791 (+)
129S1/SvImJ ENSMUSG00200031229
 protein coding gene Chr8:16392179-16394829 (+)
A/J ENSMUSG00195038509
 protein coding gene Chr8:16815265-16817915 (+)
AKR/J ENSMUSG00220030768
 protein coding gene Chr8:16543422-16546099 (+)
BALB/cJ ENSMUSG00180022311
 protein coding gene Chr8:16435630-16438280 (+)
C3H/HeJ ENSMUSG00175036708
 protein coding gene Chr8:16612799-16615449 (+)
C57BL/6NJ ENSMUSG00215013983
 protein coding gene Chr8:16515418-16518096 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J ENSMUSG00210037801
 protein coding gene Chr8:16456813-16459463 (+)
DBA/2J ENSMUSG00185006696
 protein coding gene Chr8:16580291-16582941 (+)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000027503
 protein coding gene Chr8:16480607-16483182 (+)
LP/J ENSMUSG00230019467
 protein coding gene Chr8:18623861-18626544 (+)
NOD/ShiLtJ ENSMUSG00190028994
 protein coding gene Chr8:16587230-16589880 (+)
NZO/HlLtJ ENSMUSG00225041647
 protein coding gene Chr8:26478798-26481476 (+)
PWK/PhJ ENSLUMG00010027106
 protein coding gene Chr8:16294769-16297437 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005018836
 protein coding gene Chr8:16485362-16488047 (+)



Homology
more
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Synonyms
    BD-2, DEFB102, DEFB-2, DEFB2, DEFB4, HBD-2, SAP1
  • Links
    NCBI Gene ID: 1673
    UniProt: O15263

  • Chr Location
    8p23.1
  • Human Ortholog
    DEFB4B, defensin beta 4B
  • Synonyms
    DEFB4P
  • Links
    NCBI Gene ID: 100289462

  • Chr Location
    8
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246080 NCBI Gene Model | MGI Sequence Detail 2679 C57BL/6J ±  kb
transcript NM_139220 RefSeq | MGI Sequence Detail 306 Not Specified  
polypeptide Q91V70 UniProt | EBI | MGI Sequence Detail 71 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:75063 Schutte BC, et al., Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory