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Clstn3 Gene Detail
Summary
  • Symbol
    Clstn3
  • Name
    calsyntenin 3
  • Synonyms
    alcadein-beta, Clstn3b, Cst-3, CSTN3, mKIAA0726
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178323
    NCBI Gene: 232370
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124407715-124441743 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178323
 protein coding gene Chr6:124407540-124441753 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031257
 protein coding gene Chr6:127685780-127720533 (-)
A/J MGP_AJ_G0031224
 protein coding gene Chr6:122821654-122855056 (-)
AKR/J MGP_AKRJ_G0031152
 protein coding gene Chr6:126203778-126240847 (-)
BALB/cJ MGP_BALBcJ_G0031232
 protein coding gene Chr6:122457990-122492549 (-)
C3H/HeJ MGP_C3HHeJ_G0030955
 protein coding gene Chr6:126272252-126305357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031690
 protein coding gene Chr6:131002652-131052372 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028842
 protein coding gene Chr6:120126428-120161682 (-)
CAST/EiJ MGP_CASTEiJ_G0030338
 protein coding gene Chr6:126520959-126555686 (-)
CBA/J MGP_CBAJ_G0030914
 protein coding gene Chr6:136166646-136210678 (-)
DBA/2J MGP_DBA2J_G0031070
 protein coding gene Chr6:121760372-121794503 (-)
FVB/NJ MGP_FVBNJ_G0031020
 protein coding gene Chr6:120694192-120731076 (-)
LP/J MGP_LPJ_G0031151
 protein coding gene Chr6:127894917-127931299 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031058
 protein coding gene Chr6:140135544-140169460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031721
 protein coding gene Chr6:126112358-126152044 (-)
PWK/PhJ MGP_PWKPhJ_G0030052
 protein coding gene Chr6:120007604-120041206 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029881
 protein coding gene Chr6:124245285-124280143 (-)
WSB/EiJ MGP_WSBEiJ_G0030420
 protein coding gene Chr6:126461284-126500377 (-)



Homology
more
  • Human Ortholog
    CLSTN3, calsyntenin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLSTN3, calsyntenin 3
  • Synonyms
    alcbeta, CDHR14, CSTN3
  • Links
    NCBI Gene ID: 9746
    neXtProt AC: NX_Q9BQT9
    UniProt: Q9BQT9

  • Chr Location
    12p13.31; chr12:7129093-7158945 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 7 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reductions in excitatory and inhibitory synapse density and deficits in synaptic transmission. Whole-body KO results in reduced sensitivity to diet-induced obesity, reduced body weight and fat amount and increased energy expenditure. It, and neuron-specific homozygous KO, also causes reduction in bone marrow volume, bone mass and femur length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    35
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232370 NCBI Gene Model | MGI Sequence Detail 34029 C57BL/6J ±  kb
    transcript NM_153508 RefSeq | MGI Sequence Detail 4007 C57BL/6  
    polypeptide Q99JH7 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 19
    • Earliest
      J:80943 Hintsch G, et al., The calsyntenins-a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol Cell Neurosci. 2002 Nov;21(3):393-409
    • Latest
      J:339205 Hata S, et al., Brain p3-Alcbeta peptide restores neuronal viability impaired by Alzheimer's amyloid beta-peptide. EMBO Mol Med. 2023 May 8;15(5):e17052
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory