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Trhr2 Gene Detail
Summary
  • Symbol
    Trhr2
  • Name
    thyrotropin releasing hormone receptor 2
  • Synonyms
    TRH-R2
Location &
Maps
more
  • Sequence Map
    Chr8:123083706-123087485 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 70.95 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177284
 protein coding gene Chr8:123082804-123089725 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034221
 protein coding gene Chr8:125887471-125891201 (-)
A/J MGP_AJ_G0034201
 protein coding gene Chr8:120679009-120682740 (-)
AKR/J MGP_AKRJ_G0034128
 protein coding gene Chr8:124198683-124202414 (-)
BALB/cJ MGP_BALBcJ_G0034195
 protein coding gene Chr8:120882134-120885696 (-)
C3H/HeJ MGP_C3HHeJ_G0033906
 protein coding gene Chr8:124897813-124901544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034715
 protein coding gene Chr8:130077724-130081452 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031657
 protein coding gene Chr8:113506825-113510732 (-)
CAST/EiJ MGP_CASTEiJ_G0033233
 protein coding gene Chr8:124968460-124974798 (-)
CBA/J MGP_CBAJ_G0033879
 protein coding gene Chr8:134883431-134887198 (-)
DBA/2J MGP_DBA2J_G0034035
 protein coding gene Chr8:119873153-119876912 (-)
FVB/NJ MGP_FVBNJ_G0033978
 protein coding gene Chr8:118996159-119000599 (-)
LP/J MGP_LPJ_G0034124
 protein coding gene Chr8:126019724-126023454 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034025
 protein coding gene Chr8:137055893-137059623 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034733
 protein coding gene Chr8:124380070-124385575 (-)
PWK/PhJ MGP_PWKPhJ_G0032935
 protein coding gene Chr8:119688335-119692176 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032775
 protein coding gene Chr8:123104575-123108222 (-)
WSB/EiJ MGP_WSBEiJ_G0033349
 protein coding gene Chr8:125131746-125135308 (-)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female but not male mice homozygous for a null allele display increased depression-like and decreased anxiety-like behaviors.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    17
  • cDNA Data
    4
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039079 Ensembl Gene Model | MGI Sequence Detail 3780 C57BL/6J ±  kb
transcript ENSMUST00000044123 Ensembl | MGI Sequence Detail 1340 Not Applicable  
polypeptide ENSMUSP00000042575 Ensembl | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR002120 Thyrotropin-releasing hormone receptor
  • GlyGen
    Q9ERT2 1 site
Molecular
Reagents
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  • All nucleic 7
    Genomic 2
    cDNA 4
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Phenotypes 3
  • Earliest
    J:74954 Harder S, et al., Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2). Endocrinology. 2001 Mar;142(3):1188-94
  • Latest
    J:252758 Muller-Fielitz H, et al., Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 2017 Sep 07;8(1):484
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory