Zfp287 MGI Mouse Gene Detail - MGI:2176561

Symbol

Zfp287
Name

zinc finger protein 287
Synonyms

B230333C16Rik, SKAT-2

Feature Type

protein coding gene
IDs

MGI:2176561
NCBI Gene: 170740
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:62591182-62622731 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 38.62 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2176561	protein coding gene	Chr11:62583270-62622749 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018460	protein coding gene	Chr11:62765199-62801081 (-)
A/J	MGP_AJ_G0018429	protein coding gene	Chr11:60440269-60475164 (-)
AKR/J	MGP_AKRJ_G0018398	protein coding gene	Chr11:62304784-62337186 (-)
BALB/cJ	MGP_BALBcJ_G0018400	protein coding gene	Chr11:60718070-60749102 (-)
C3H/HeJ	MGP_C3HHeJ_G0018213	protein coding gene	Chr11:62282002-62312905 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018852	protein coding gene	Chr11:64744310-64780431 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016497	protein coding gene	Chr11:57524260-57554513 (-)
CAST/EiJ	MGP_CASTEiJ_G0017769	protein coding gene	Chr11:62428517-62462776 (-)
CBA/J	MGP_CBAJ_G0018187	protein coding gene	Chr11:67526745-67563730 (-)
DBA/2J	MGP_DBA2J_G0018296	protein coding gene	Chr11:59996978-60027760 (-)
FVB/NJ	MGP_FVBNJ_G0018286	protein coding gene	Chr11:59664132-59695479 (-)
LP/J	MGP_LPJ_G0018368	protein coding gene	Chr11:63309819-63342569 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018310	protein coding gene	Chr11:68511637-68543705 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018893	protein coding gene	Chr11:62463848-62497018 (-)
PWK/PhJ	MGP_PWKPhJ_G0017543	protein coding gene	Chr11:60614188-60644284 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017333	protein coding gene	Chr11:62304397-62334803 (-)
WSB/EiJ	MGP_WSBEiJ_G0017822	protein coding gene	Chr11:62077868-62109548 (-)

Human Ortholog

ZNF287, zinc finger protein 287

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF287, zinc finger protein 287
Synonyms

ZKSCAN13, ZSCAN45
Links

HGNC:13502

NCBI Gene ID: 57336

neXtProt AC: NX_Q9HBT7

UniProt: Q9HBT7
Chr Location

17p11.2; chr17:16546954-16569212 (-) GRCh38

MGI Vertebrate Homology

Zfp287 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZNF287
Gene Tree

Zfp287

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Zfp287
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

122
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

84
RefSeq

33
UniProt

8
CCDS

CCDS24830.1

Ensembl

ENSMUSG00000005267 (Evidence)
NCBI Gene

170740

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005267	Ensembl Gene Model \| MGI Sequence Detail	31550	C57BL/6J	± kb
transcript	ENSMUST00000149228	Ensembl \| MGI Sequence Detail	3391	Not Applicable
polypeptide	ENSMUSP00000114531	Ensembl \| MGI Sequence Detail	759	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000017810 zinc finger protein 287

(term hierarchy)
InterPro Domains

IPR036051 KRAB domain superfamily

IPR001909 Krueppel-associated box

IPR003309 SCAN domain

IPR038269 SCAN domain superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 3

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MGI:2442938

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Zfp287:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108437	Chr11:62622691-62622736 (-)	17 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23