Vps37d MGI Mouse Gene Detail - MGI:2159402 - vacuolar protein sorting 37D

Symbol

Vps37d
Name

vacuolar protein sorting 37D
Synonyms

MGC:51411, Wbscr24

Feature Type

protein coding gene
IDs

MGI:2159402
NCBI Gene: 194309
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:135101754-135107120 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 74.98 cM
Mapping Data

1 experiment

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159402	protein coding gene	Chr5:135101751-135107197 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030173	protein coding gene	Chr5:139571467-139576807 (-)
A/J	MGP_AJ_G0030141	protein coding gene	Chr5:133597215-133602519 (-)
AKR/J	MGP_AKRJ_G0030074	protein coding gene	Chr5:137940378-137945744 (-)
BALB/cJ	MGP_BALBcJ_G0030151	protein coding gene	Chr5:134955035-134960401 (-)
C3H/HeJ	MGP_C3HHeJ_G0029867	protein coding gene	Chr5:138502738-138508104 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030604	protein coding gene	Chr5:144796601-144801968 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027827	protein coding gene	Chr5:127895806-127901161 (-)
CAST/EiJ	MGP_CASTEiJ_G0029276	protein coding gene	Chr5:137922815-137928181 (-)
CBA/J	MGP_CBAJ_G0029837	protein coding gene	Chr5:150463431-150468797 (-)
DBA/2J	MGP_DBA2J_G0029988	protein coding gene	Chr5:133500684-133506024 (-)
FVB/NJ	MGP_FVBNJ_G0029943	protein coding gene	Chr5:132634785-132640159 (-)
LP/J	MGP_LPJ_G0030076	protein coding gene	Chr5:140018007-140024892 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029975	protein coding gene	Chr5:153479082-153484465 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030644	protein coding gene	Chr5:137687559-137692899 (-)
PWK/PhJ	MGP_PWKPhJ_G0028991	protein coding gene	Chr5:132542156-132547553 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028826	protein coding gene	Chr5:135240397-135253260 (-)
WSB/EiJ	MGP_WSBEiJ_G0029350	protein coding gene	Chr5:138439586-138444908 (-)

Human Ortholog

VPS37D, VPS37D subunit of ESCRT-I

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VPS37D, VPS37D subunit of ESCRT-I
Synonyms

WBSCR24
Links

HGNC:18287

NCBI Gene ID: 155382

neXtProt AC: NX_Q86XT2

UniProt: Q86XT2
Chr Location

7q11.23; chr7:73665347-73672112 (+) GRCh38

MGI Vertebrate Homology

Vps37d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VPS37D
Gene Tree

Vps37d

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References

2 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

1
Targeted

6
Genomic Mutations

2 involving Vps37d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

13
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

8
UniProt

1
CCDS

CCDS19733.1, CCDS57388.1

Ensembl

ENSMUSG00000043614 (Evidence)
NCBI Gene

194309

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043614	Ensembl Gene Model \| MGI Sequence Detail	5367	C57BL/6J	± kb
transcript	ENSMUST00000067935	Ensembl \| MGI Sequence Detail	1544	Not Applicable
polypeptide	ENSMUSP00000063762	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017338 vacuolar protein sorting-associated protein 37D

(term hierarchy)
InterPro Domains

IPR009851 Modifier of rudimentary, Modr

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All nucleic 11

cDNA 11

Microarray probesets 2

Summaries

All 46

Developmental Gene Expression 1

Diseases 2

Gene Ontology 4

Phenotypes 21
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:337436 Abdalla N, et al., Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12)

TSS for Vps37d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53727	Chr5:135107168-135107200 (-)	-64 bp
Tssr53726	Chr5:135107130-135107165 (-)	-28 bp
Tssr53725	Chr5:135107078-135107114 (-)	24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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