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Ms4a3 Gene Detail
Summary
  • Symbol
    Ms4a3
  • Name
    membrane-spanning 4-domains, subfamily A, member 3
  • Synonyms
    haematopoietic cell-specific transmembrane-4, HTm4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158468
    NCBI Gene: 170813
  • Member of
    Ms4ac cluster
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11606863-11618215 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.47 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158468
 protein coding gene Chr19:11606860-11618215 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024880
 protein coding gene Chr19:9021435-9032790 (-)
A/J MGP_AJ_G0024854
 protein coding gene Chr19:8507096-8518451 (-)
AKR/J MGP_AKRJ_G0024829
 protein coding gene Chr19:8832683-8844038 (-)
BALB/cJ MGP_BALBcJ_G0024854
 protein coding gene Chr19:8509977-8521324 (-)
C3H/HeJ MGP_C3HHeJ_G0024620
 protein coding gene Chr19:8733984-8745339 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025302
 protein coding gene Chr19:9469488-9480843 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022726
 protein coding gene Chr19:8865405-8876406 (-)
CAST/EiJ MGP_CASTEiJ_G0024093
 protein coding gene Chr19:8316629-8327975 (-)
CBA/J MGP_CBAJ_G0024594
 protein coding gene Chr19:9523004-9534357 (-)
DBA/2J MGP_DBA2J_G0024721
 protein coding gene Chr19:8475593-8486952 (-)
FVB/NJ MGP_FVBNJ_G0024688
 protein coding gene Chr19:8508936-8520324 (-)
LP/J MGP_LPJ_G0024808
 protein coding gene Chr19:9019835-9031190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024715
 protein coding gene Chr19:9423562-9439495 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025350
 protein coding gene Chr19:8813849-8825204 (-)
PWK/PhJ MGP_PWKPhJ_G0023837
 protein coding gene Chr19:7930591-7942760 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023643
 protein coding gene Chr19:7970128-7981471 (-)
WSB/EiJ MGP_WSBEiJ_G0024155
 protein coding gene Chr19:8664136-8679062 (-)



Homology
more
  • Human Ortholog
    MS4A3, membrane spanning 4-domains A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MS4A3, membrane spanning 4-domains A3
  • Synonyms
    CD20L, HTM4
  • Links
    NCBI Gene ID: 932
    neXtProt AC: NX_Q96HJ5
    UniProt: Q96HJ5

  • Chr Location
    11q12.1; chr11:60056628-60071116 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    89
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170813 NCBI Gene Model | MGI Sequence Detail 11353 C57BL/6J ±  kb
    transcript NM_133246 RefSeq | MGI Sequence Detail 1009 C57BL/6  
    polypeptide Q920C4 UniProt | EBI | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:68334 Liang Y, et al., Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001 Mar 1;72(2):119-27
    • Latest
      J:333419 Rebejac J, et al., Meningeal macrophages protect against viral neuroinfection. Immunity. 2022 Nov 8;55(11):2103-2117.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    05/24/2023
    MGI 6.22     		The Jackson Laboratory