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Rtkn2 Gene Detail
Summary
  • Symbol
    Rtkn2
  • Name
    rhotekin 2
  • Synonyms
    B130039D23Rik, Mbf, Plekhk1, RTKN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158417
    NCBI Gene: 170799
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:67815371-67894259 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 35.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158417
 protein coding gene Chr10:67815371-67895570 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017328
 protein coding gene Chr10:67766209-67851733 (+)
A/J MGP_AJ_G0017305
 protein coding gene Chr10:65500040-65580657 (+)
AKR/J MGP_AKRJ_G0017266
 protein coding gene Chr10:67282124-67366130 (+)
BALB/cJ MGP_BALBcJ_G0017265
 protein coding gene Chr10:65703266-65785586 (+)
C3H/HeJ MGP_C3HHeJ_G0017089
 protein coding gene Chr10:67281929-67367109 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017723
 protein coding gene Chr10:70202182-70286788 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015413
 protein coding gene Chr10:62180088-62268768 (+)
CAST/EiJ MGP_CASTEiJ_G0016659
 protein coding gene Chr10:67342509-67427610 (+)
CBA/J MGP_CBAJ_G0017061
 protein coding gene Chr10:72884259-72968700 (+)
DBA/2J MGP_DBA2J_G0017166
 protein coding gene Chr10:64882040-64963887 (+)
FVB/NJ MGP_FVBNJ_G0017159
 protein coding gene Chr10:64045341-64128209 (+)
LP/J MGP_LPJ_G0017239
 protein coding gene Chr10:68184572-68274031 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017187
 protein coding gene Chr10:75087650-75178471 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017762
 protein coding gene Chr10:67179598-67263491 (+)
PWK/PhJ MGP_PWKPhJ_G0016443
 protein coding gene Chr10:64683934-64765372 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016225
 protein coding gene Chr10:66562196-66644082 (+)
WSB/EiJ MGP_WSBEiJ_G0016723
 protein coding gene Chr10:67126417-67210512 (+)



Homology
more
  • Human Ortholog
    RTKN2, rhotekin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTKN2, rhotekin 2
  • Synonyms
    bA531F24.1, PLEKHK1
  • Links
    NCBI Gene ID: 219790
    neXtProt AC: NX_Q8IZC4
    UniProt: Q8IZC4

  • Chr Location
    10q21.2; chr10:62183035-62268844 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    12
  • cDNA Data
    22
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 170799 NCBI Gene Model | MGI Sequence Detail 78889 C57BL/6J ±  kb
transcript NM_001359318 RefSeq | MGI Sequence Detail 3966 C57BL/6  
polypeptide Q14B46 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2444494
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345362 Hutchison V, et al., Inducible tricolor reporter mouse for parallel imaging of lysosomes, mitochondria, and microtubules. J Cell Biol. 2024 Jan 1;223(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory