Dppa2 MGI Mouse Gene Detail - MGI:2157523 - developmental pluripotency associated 2

Symbol

Dppa2
Name

developmental pluripotency associated 2
Synonyms

2410088E07Rik, ECAT15-2

Feature Type

protein coding gene
IDs

MGI:2157523
NCBI Gene: 73703
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr16:48130637-48139876 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.75 cM
Mapping Data

1 experiment

SNPs within 2kb

362 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2157523	protein coding gene	Chr16:48124271-48140086 (+)
129S1/SvImJ	ENSMUSG00200021318	protein coding gene	Chr16:44987227-45003072 (+)
A/J	ENSMUSG00195003384	protein coding gene	Chr16:44611200-44627022 (+)
AKR/J	ENSMUSG00220021594	protein coding gene	Chr16:44956449-44972272 (+)
BALB/cJ	ENSMUSG00180026253	protein coding gene	Chr16:44815949-44831767 (+)
C3H/HeJ	ENSMUSG00175024426	protein coding gene	Chr16:45093817-45109873 (+)
C57BL/6NJ	ENSMUSG00215005428	protein coding gene	Chr16:44920421-44936241 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020791	protein coding gene	Chr16:45237168-45247391 (+)
CAST/EiJ	ENSTCUG00005012408	protein coding gene	Chr16:45230635-45246247 (+)
CBA/J	ENSMUSG00210016376	protein coding gene	Chr16:45123928-45139977 (+)
DBA/2J	ENSMUSG00185010167	protein coding gene	Chr16:44995502-45011319 (+)
FVB/NJ	ENSMUSG00205011683	protein coding gene	Chr16:44905238-44921033 (+)
JF1/MsJ	ENSUMUG00000015522	protein coding gene	Chr16:45230262-45246341 (+)
LP/J	ENSMUSG00230025954	protein coding gene	Chr16:47561845-47577658 (+)
NOD/ShiLtJ	ENSMUSG00190017071	protein coding gene	Chr16:45009131-45024949 (+)
NZO/HlLtJ	ENSMUSG00225025425	protein coding gene	Chr16:50653677-50669493 (+)
PWK/PhJ	ENSLUMG00010025796	protein coding gene	Chr16:45074391-45090476 (+)
SPRET/EiJ	ENSMSPG00010007264	protein coding gene	Chr16:45284977-45294122 (+)
WSB/EiJ	ENSIUOG00005012900	protein coding gene	Chr16:45199148-45214992 (+)

Human Ortholog

DPPA2, developmental pluripotency associated 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DPPA2, developmental pluripotency associated 2
Synonyms

CT100, ECAT15-2, PESCRG1
Links

HGNC:19197

NCBI Gene ID: 151871

UniProt: Q7Z7J5
Chr Location

3q13.13; chr3:109293788-109316517 (-) GRCh38

MGI Vertebrate Homology

Dppa2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DPPA2
Gene Tree

Dppa2

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Phenotype Summary

2 phenotypes from 2 alleles in 1 genetic background
16 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Endonuclease-mediated

2
Gene trapped

36
Targeted

7
Genomic Mutations

1 involving Dppa2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

Mice homozygous for a null allele do not survive to weaning.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

696
Tissues

38
cDNA Data

44
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

2
CCDS

CCDS37350.1

Ensembl

ENSMUSG00000072419 (Evidence)
NCBI Gene

73703

			Length	Strain/Species	Flank
genomic	73703	NCBI Gene Model \| MGI Sequence Detail	9240	C57BL/6J	± kb
transcript	NM_028615	RefSeq \| MGI Sequence Detail	1941	Not Specified
polypeptide	Q9CWH0	UniProt \| EBI \| MGI Sequence Detail	301	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006665 developmental pluripotency-associated protein 2

(term hierarchy)
InterPro Domains

IPR039590 Developmental pluripotency-associated protein 2/4

IPR025892 Developmental pluripotency-associated protein 2/4, central domain

IPR025891 Developmental pluripotency-associated protein 2/4, C-terminal domain

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All nucleic 47

cDNA 44

Primer pair 3

Antibodies 2

Microarray probesets 5

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MGI:1920953

Summaries

All 51

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:316936 Kubinyecz O, et al., Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival. Development. 2021 Dec 15;148(24):dev200191

TSS for Dppa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138652	Chr16:48130528-48130551 (+)	-97 bp
Tssr138653	Chr16:48130790-48130829 (+)	173 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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