Elovl6 MGI Mouse Gene Detail - MGI:2156528 - ELOVL fatty acid elongase 6

Symbol

Elovl6
Name

ELOVL fatty acid elongase 6
Synonyms

ELOVL family member 6, elongation of long chain fatty acids (yeast), FEN1/Elo2, SUR4/Elo3-like, LCE

Feature Type

protein coding gene
IDs

MGI:2156528
NCBI Gene: 170439
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:129326035-129432144 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 58.05 cM
Mapping Data

2 experiments

SNPs within 2kb

656 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2156528	protein coding gene	Chr3:129326004-129432144 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027870	protein coding gene	Chr3:132193009-132297133 (+)
A/J	MGP_AJ_G0027828	protein coding gene	Chr3:127606501-127712663 (+)
AKR/J	MGP_AKRJ_G0027793	protein coding gene	Chr3:130912962-131018730 (+)
BALB/cJ	MGP_BALBcJ_G0027841	protein coding gene	Chr3:127444021-127549604 (+)
C3H/HeJ	MGP_C3HHeJ_G0027570	protein coding gene	Chr3:131302128-131407760 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028285	protein coding gene	Chr3:136930382-137046029 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025623	protein coding gene	Chr3:123130060-123236963 (+)
CAST/EiJ	MGP_CASTEiJ_G0027027	protein coding gene	Chr3:130969502-131089384 (+)
CBA/J	MGP_CBAJ_G0027546	protein coding gene	Chr3:141553990-141659614 (+)
DBA/2J	MGP_DBA2J_G0027687	protein coding gene	Chr3:126795783-126901588 (+)
FVB/NJ	MGP_FVBNJ_G0027654	protein coding gene	Chr3:124372244-124478631 (+)
LP/J	MGP_LPJ_G0027796	protein coding gene	Chr3:133709139-133815568 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027685	protein coding gene	Chr3:149499178-149601042 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028342	protein coding gene	Chr3:130574419-130688143 (+)
PWK/PhJ	MGP_PWKPhJ_G0026751	protein coding gene	Chr3:126524808-126632076 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026576	protein coding gene	Chr3:128637032-128744178 (+)
WSB/EiJ	MGP_WSBEiJ_G0027106	protein coding gene	Chr3:131283590-131392355 (+)

Human Ortholog

ELOVL6, ELOVL fatty acid elongase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELOVL6, ELOVL fatty acid elongase 6
Synonyms

FACE, FAE, hELO2, LCE
Links

HGNC:15829

NCBI Gene ID: 79071

neXtProt AC: NX_Q9H5J4

UniProt: Q9H5J4
Chr Location

4q25; chr4:110045846-110199202 (-) GRCh38

MGI Vertebrate Homology

Elovl6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ELOVL6
Gene Tree

Elovl6

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References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 2 alleles in 3 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

273
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

261
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Elovl6
Incidental Mutations

APF
Find Mice (IMSR)

252 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null gene trap mutation exhibit enhanced motor coordination. Female homozygotes exhibit decreased serum cholesterol levels.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

845
Tissues

133
cDNA Data

168
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase elovl6

ZFIN elovl6

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All Sequences

55
RefSeq

2
UniProt

4
CCDS

CCDS38632.1

Ensembl

ENSMUSG00000041220 (Evidence)
NCBI Gene

170439

			Length	Strain/Species	Flank
genomic	170439	NCBI Gene Model \| MGI Sequence Detail	106110	C57BL/6J	± kb
transcript	NM_130450	RefSeq \| MGI Sequence Detail	5951	C57BL/6
polypeptide	Q920L5	UniProt \| EBI \| MGI Sequence Detail	267	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007041 very long chain fatty acid elongase 6

(term hierarchy)
EC

2.3.1.199
InterPro Domains

IPR002076 ELO family

IPR030457 ELO family, conserved site

IPR033675 Elongation of very long chain fatty acids protein 6

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All nucleic 174

cDNA 169

Primer pair 5

Microarray probesets 5

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MGI:2140052

Summaries

All 79

Developmental Gene Expression 15

Diseases 1

Gene Ontology 8

Phenotypes 32
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:335426 Butera A, et al., ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423

TSS for Elovl6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31642	Chr3:129326046-129326089 (+)	33 bp
Tssr31643	Chr3:129326102-129326159 (+)	96 bp
Tssr31644	Chr3:129326285-129326293 (+)	254 bp
Tssr31645	Chr3:129327302-129327306 (+)	1,269 bp
Tssr31646	Chr3:129347100-129347118 (+)	21,074 bp
Tssr31647	Chr3:129406506-129406517 (+)	80,477 bp
Tssr31648	Chr3:129412761-129412768 (+)	86,730 bp
Tssr31649	Chr3:129418080-129418084 (+)	92,047 bp
Tssr31650	Chr3:129428347-129428360 (+)	102,319 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23